4-(TRIFLUOROMETHYL)CYCLOHEXANOL
- CAS No.
- 30129-18-1
- Chemical Name:
- 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
- Synonyms
- 4-(TRIFLUOROMETHYL)CYCLOHEXANOL;4-(TRIFLUOROMETHYL)CYCLOHEXAN-1-OL;Cyclohexanol, 4-(trifluoromethyl)-;4-(trifluoromethyl)-1-cyclohexanol;1-Hydroxy-4-(trifluoromethyl)cyclohexane;4-(TRIFLUOROMETHYL)CYCLOHEXANOL, CIS/TRANS;4-(TRIFLUOROMETHYL)CYCLOHEXANOL (CIS/TRANS MIXTURE);4-(trifluoromethyl)cyclohexan-1-ol, cis/trans mixture;4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture);4-(Trifluoromethyl)cyclohexanol (mixture of cis-and trans-)
- CBNumber:
- CB8726496
- Molecular Formula:
- C7H11F3O
- Molecular Weight:
- 168.16
- MDL Number:
- MFCD00102144
- MOL File:
- 30129-18-1.mol
| Boiling point | 78 °C |
|---|---|
| Density | 1.23 |
| refractive index | 1.4070 to 1.4110 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | clear liquid |
| pka | 14.88±0.40(Predicted) |
| color | Colorless to Almost colorless |
| Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
| InChI | InChI=1S/C7H11F3O/c8-7(9,10)5-1-3-6(11)4-2-5/h5-6,11H,1-4H2 |
| InChIKey | VJUJYNJEPPWWHS-UHFFFAOYSA-N |
| SMILES | C1(O)CCC(C(F)(F)F)CC1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2906190090 | |||||||||
| NFPA 704 |
|
4-(TRIFLUOROMETHYL)CYCLOHEXANOL price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000014 | 4-(Trifluoromethyl)cyclohexanol Aldrich | 30129-18-1 | 1g | $70.9 | 2024-03-01 | Buy |
| TCI Chemical | T2706 | 4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture) >98.0%(GC) | 30129-18-1 | 5g | $192 | 2024-03-01 | Buy |
| Alfa Aesar | H33317 | 4-(Trifluoromethyl)cyclohexanol, 97% | 30129-18-1 | 1g | $77.65 | 2024-03-01 | Buy |
| Alfa Aesar | H33317 | 4-(Trifluoromethyl)cyclohexanol, 97% | 30129-18-1 | 5g | $292.65 | 2024-03-01 | Buy |
| TRC | T797043 | 4-(Trifluoromethyl)cyclohexanol | 30129-18-1 | 50mg | $45 | 2021-12-16 | Buy |
4-(TRIFLUOROMETHYL)CYCLOHEXANOL Chemical Properties,Uses,Production
Uses
It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.
Synthesis
402-45-9
75091-92-8
Step A: Synthesis of 4-(trifluoromethyl)cyclohexanol; 4-hydroxytrifluorotoluene (5 g, 30.8 mmol) was placed in a high-pressure hydrogenation reactor, dissolved in acetic acid (15 ml) and platinum oxide (PtO, 500 mg) was added as a catalyst. The reactor was pressurized using hydrogen (50 psi) and the reaction was carried out at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the pH was adjusted by adding 1N sodium hydroxide solution to the filtrate, followed by extraction with diethyl ether. The organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure at room temperature to afford the target product 4-(trifluoromethyl)cyclohexanol (4.5 g, 87% yield). Mass spectrometry analysis showed [M + H]+ peak of 169, corresponding to the molecular ion peak (M + 1).
References
[1] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 27
[2] , 1970, vol. 6, # 10, p. 2063 - 2067
[3] Zhurnal Organicheskoi Khimii, 1970, vol. 6, # 10, p. 2055 - 2060
4-(TRIFLUOROMETHYL)CYCLOHEXANOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3944 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 6388 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Hebei Bonster Technology Co.,Limited | +86-13315996897 | bsterltd.wendy@gmail.com | China | 792 | 58 |
| Pharmahands (Taizhou) Co., Ltd. | +86 523-86200360 | CHINA | 358 | 58 |
View Lastest Price from 4-(TRIFLUOROMETHYL)CYCLOHEXANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-25 | 4-(trifluoromethyl)cyclohexanol
30129-18-1
|
US $0.00 / gm | 100gm | 97%min | 100kgs | Shanghai Yongzeng Technology Co.,Ltd | |
 |
2025-06-24 | 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
30129-18-1
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2024-07-18 | 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
30129-18-1
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-(trifluoromethyl)cyclohexanol
30129-18-1
- US $0.00 / gm
- 97%min
- Shanghai Yongzeng Technology Co.,Ltd
-
- 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
30129-18-1
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
30129-18-1
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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