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ChemicalBook >> CAS DataBase List >>BR102375

BR102375

CAS No.
2366255-59-4
Chemical Name:
BR102375
Synonyms
BR102375;BR-102375,BR102375;4(3H)-Pyrimidinone, 2-butyl-3-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-5-[[3-(1,1-dimethylethyl)-1,2,4-oxadiazol-5-yl]methyl]-6-methyl-
CBNumber:
CB85821273
Molecular Formula:
C31H34N6O4
Molecular Weight:
554.64
MDL Number:
MFCD32174290
MOL File:
2366255-59-4.mol
Last updated:2025-04-18 09:52:56

BR102375 Properties

Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 6.97±0.20(Predicted)

BR102375 Chemical Properties,Uses,Production

Uses

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%[1].

in vivo

BR102375 (Compound 18) has decent efficacy on mouse diabetes model[1]. BR102375 reveals significant suppressive effect on random blood glucose increase(75 mpk, p.o., bid), shows decent effect on insulin resistance on Oral glucose tolerance test (OGTT) and discloses similar findings in body weight gain almost identical to Pioglitazone[1].

References

[1] Choung W, et al. Discovery of BR102375, a new class of non-TZD PPARγ full agonist for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Jun 19. pii: S0960-894X(19)30407-X. DOI:10.1016/j.bmcl.2019.06.027
[2] Yan Zhu, et al. Protective Role of Long Noncoding RNA CRNDE in Myocardial Tissues From Injury Caused by Sepsis Through the microRNA-29a/SIRT1 Axis. Life Sci. 2020 May 27;117849. DOI:10.1016/j.lfs.2020.117849

BR102375 Preparation Products And Raw materials

Raw materials

Preparation Products

BR102375 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26070 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58

View Lastest Price from BR102375 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BR102375 pictures 2024-10-24 BR102375
2366255-59-4
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
  • BR102375 pictures
  • BR102375
    2366255-59-4
  • US $1520.00-2500.00 / mg
  • TargetMol Chemicals Inc.
BR102375 4(3H)-Pyrimidinone, 2-butyl-3-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-5-[[3-(1,1-dimethylethyl)-1,2,4-oxadiazol-5-yl]methyl]-6-methyl- BR-102375,BR102375 2366255-59-4