2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- CAS No.
- 277299-70-4
- Chemical Name:
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- Synonyms
- 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;EltroMbopag II;ELTROMBOPAG INT;Eltrombopag Impurity 35;Eltrombopag Intermediate 1;Eltrombopag olamine Intermediate 4;1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol;2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
- CBNumber:
- CB82490074
- Molecular Formula:
- C12H14N2O
- Molecular Weight:
- 202.25
- MDL Number:
- MFCD09795980
- MOL File:
- 277299-70-4.mol
Melting point | 121.0 to 125.0 °C |
---|---|
Boiling point | 338.5±52.0 °C(Predicted) |
Density | 1.121 |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 0.79±0.40(Predicted) |
color | Pale Beige to Light Beige |
InChI | InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3 |
InChIKey | HBWBJCSXUJIDGN-UHFFFAOYSA-N |
SMILES | N1C(C)=CC(=O)N1C1=CC=C(C)C(C)=C1 |
FDA UNII | 2AK83UFD4X |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H335-H319-H315 |
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
HS Code | 2933.19.9000 |
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | D5064 | 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone >97.0%(GC)(T) | 277299-70-4 | 1g | $52 | 2025-07-31 | Buy |
TCI Chemical | D5064 | 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone >97.0%(GC)(T) | 277299-70-4 | 5g | $261 | 2025-07-31 | Buy |
TRC | D476930 | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one | 277299-70-4 | 10g | $580 | 2021-12-16 | Buy |
AK Scientific | Y6618 | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one | 277299-70-4 | 5g | $156 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | APN0000595 | 2-(3,4-DIMETHYL-PHENYL)-5-METHYL-1,2-DIHYDRO-PYRAZOL-3-ONE 95.00% | 277299-70-4 | 1G | $975.45 | 2021-12-16 | Buy |
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties,Uses,Production
Uses
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
Synthesis

141-97-9

60481-51-8

277299-70-4
1. In 250 mL of glacial acetic acid, 3,4-dimethylphenylhydrazine hydrochloride (17.7 g, 0.1 mol), ethyl acetoacetate (13.0 g, 0.1 mol), and sodium acetate (8.2 g, 0.1 mol) were added, and mixed with stirring. 2. The reaction mixture was heated to reflux for 24 hours. 3. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation. 4. The residue was dissolved in 1 L of ether and washed carefully with saturated aqueous sodium bicarbonate (5 x 200 mL). 5. The ether layer was separated and the ether was removed by evaporation to afford the target product 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one (15.4 g, 76% yield). 6. The product was subjected to 1H NMR. 6. The product was confirmed by 1H NMR (300 MHz, d6-DMSO) and mass spectrometry (ES) with the following characterization data: 1H NMR δ 11.30 (br s, 1H), 7.49 (d, J = 1.4 Hz, 1H), 7.43 (dd, J = 8.2 Hz, 1H), 7.14 (d, J = 8.2 Hz, 1H), 5.31 (s, 1H ), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H); MS (ES) m/z 203 [M + H].
References
[1] Patent: US2004/53299, 2004, A1
[2] Patent: US2004/19190, 2004, A1. Location in patent: Page 17
[3] Patent: WO2016/35018, 2016, A1. Location in patent: Page/Page column 13



2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
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Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-17396673057 | linda@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
View Lastest Price from 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-07-08 | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
|
US $0.00-0.00 / kg | 1kg | 99% | 500KG | Hangzhou ICH Biofarm Co., Ltd | |
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2025-04-04 | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2025-04-02 | 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
|
US $0.00 / kg | 1kg | 99% | 20tons | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
- US $0.00-0.00 / kg
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd