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ChemicalBook >> CAS DataBase List >>2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

CAS No.
277299-70-4
Chemical Name:
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Synonyms
2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;EltroMbopag II;ELTROMBOPAG INT;Eltrombopag Impurity 35;Eltrombopag Intermediate 1;Eltrombopag olamine Intermediate 4;1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol;2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
CBNumber:
CB82490074
Molecular Formula:
C12H14N2O
Molecular Weight:
202.25
MDL Number:
MFCD09795980
MOL File:
277299-70-4.mol
Last updated:2025-07-24 18:13:48

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Properties

Melting point 121.0 to 125.0 °C
Boiling point 338.5±52.0 °C(Predicted)
Density 1.121
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 0.79±0.40(Predicted)
color Pale Beige to Light Beige
InChI InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3
InChIKey HBWBJCSXUJIDGN-UHFFFAOYSA-N
SMILES N1C(C)=CC(=O)N1C1=CC=C(C)C(C)=C1
FDA UNII 2AK83UFD4X

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H335-H319-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
HS Code  2933.19.9000

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D5064 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone >97.0%(GC)(T) 277299-70-4 1g $52 2025-07-31 Buy
TCI Chemical D5064 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone >97.0%(GC)(T) 277299-70-4 5g $261 2025-07-31 Buy
TRC D476930 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4 10g $580 2021-12-16 Buy
AK Scientific Y6618 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4 5g $156 2021-12-16 Buy
American Custom Chemicals Corporation APN0000595 2-(3,4-DIMETHYL-PHENYL)-5-METHYL-1,2-DIHYDRO-PYRAZOL-3-ONE 95.00% 277299-70-4 1G $975.45 2021-12-16 Buy
Product number Packaging Price Buy
D5064 1g $52 Buy
D5064 5g $261 Buy
D476930 10g $580 Buy
Y6618 5g $156 Buy
APN0000595 1G $975.45 Buy

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties,Uses,Production

Uses

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Synthesis

Ethyl acetoacetate

141-97-9

3,4-Dimethylphenylhydrazine hydrochloride

60481-51-8

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

277299-70-4

1. In 250 mL of glacial acetic acid, 3,4-dimethylphenylhydrazine hydrochloride (17.7 g, 0.1 mol), ethyl acetoacetate (13.0 g, 0.1 mol), and sodium acetate (8.2 g, 0.1 mol) were added, and mixed with stirring. 2. The reaction mixture was heated to reflux for 24 hours. 3. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation. 4. The residue was dissolved in 1 L of ether and washed carefully with saturated aqueous sodium bicarbonate (5 x 200 mL). 5. The ether layer was separated and the ether was removed by evaporation to afford the target product 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one (15.4 g, 76% yield). 6. The product was subjected to 1H NMR. 6. The product was confirmed by 1H NMR (300 MHz, d6-DMSO) and mass spectrometry (ES) with the following characterization data: 1H NMR δ 11.30 (br s, 1H), 7.49 (d, J = 1.4 Hz, 1H), 7.43 (dd, J = 8.2 Hz, 1H), 7.14 (d, J = 8.2 Hz, 1H), 5.31 (s, 1H ), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H); MS (ES) m/z 203 [M + H].

References

[1] Patent: US2004/53299, 2004, A1
[2] Patent: US2004/19190, 2004, A1. Location in patent: Page 17
[3] Patent: WO2016/35018, 2016, A1. Location in patent: Page/Page column 13

141-97-9
13636-53-8
277299-70-4
Synthesis of 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one from Ethyl acetoacetate and 3,4-Dimethylphenylhydrazine hydrochloride
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View Lastest Price from 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one pictures 2025-07-08 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
 US $0.00-0.00 / kg 1kg 99% 500KG Hangzhou ICH Biofarm Co., Ltd
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one pictures 2025-04-04 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
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2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one pictures 2025-04-02 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
277299-70-4
 US $0.00 / kg 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Spectrum

277299-70-4(2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one)Related Search:

2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 2-(3,4-Dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one Eltrombopag Intermediate 1 EltroMbopag II 2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine 1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol 1H-pyrazol-3(2H)-one,2-(3,4-Dimethylphenyl)-5-methyl- 2-(3,4-Dimethyl-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone Eltrombopag olamine Intermediate 4 3H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one ISO 9001：2015 REACH ELTROMBOPAG INT TIANFU CHEM 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Eltrombopag Impurity 35 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one 2-(3,4-dimethylphenyl)-5-methyl-1,2- dihydroxypyrazol-3-one 2-(3,4-Dimethyl phenpyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4 77299-70-4