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Anatibant 2HCl(209733-45-9 Free base)

CAS No.
209788-45-4
Chemical Name:
Anatibant 2HCl(209733-45-9 Free base)
Synonyms
Anatibant 2HCl;2-Pyrrolidinecarboxamide, N-[3-[[4-(aminoiminomethyl)benzoyl]amino]propyl]-1-[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl]-, hydrochloride (1:2), (2S)-
CBNumber:
CB814313866
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2025-04-18 09:52:52

Anatibant 2HCl(209733-45-9 Free base) Properties

form Solid

Anatibant 2HCl(209733-45-9 Free base) Chemical Properties,Uses,Production

Uses

Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases[1][2].

IC 50

Bradykinin B2 Receptor (B2R): 0.67 nM (Ki, human recombinant B2 receptor ); Bradykinin B2 Receptor (B2R): 1.74 nM (Ki, Rat recombinant B2 receptor ); Bradykinin B2 Receptor (B2R): 1.37 nM (Ki, Guinea-pig recombinant B2 receptor )

References

[1] Klaus Zweckberger, et al. Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neurosci Lett. 2009 Apr 24;454(2):115-7. DOI:10.1016/j.neulet.2009.02.014
[2] D Pruneau, et al. Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist. Immunopharmacology. 1999 Sep;43(2-3):187-94. DOI:10.1016/s0162-3109(99)00128-9

Anatibant 2HCl(209733-45-9 Free base) Preparation Products And Raw materials

Raw materials

Preparation Products

Anatibant 2HCl(209733-45-9 Free base) Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32367 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 25433 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58

View Lastest Price from Anatibant 2HCl(209733-45-9 Free base) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Anatibant 2HCl pictures 2025-05-01 Anatibant 2HCl
209788-45-4
 US $350.00-1200.00 / mg 99.71% 10g TargetMol Chemicals Inc.
  • Anatibant 2HCl pictures
  • Anatibant 2HCl
    209788-45-4
  • US $350.00-1200.00 / mg
  • 99.71%
  • TargetMol Chemicals Inc.
Anatibant 2HCl 2-Pyrrolidinecarboxamide, N-[3-[[4-(aminoiminomethyl)benzoyl]amino]propyl]-1-[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl]-, hydrochloride (1:2), (2S)- 209788-45-4