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ChemicalBook >> CAS DataBase List >>Bifonazole

Bifonazole

CAS No.
60628-96-8
Chemical Name:
Bifonazole
Synonyms
mycospor;bifonazol;1-[phenyl-(4-phenylphenyl)-methyl]imidazole;Amycor;Bedrid;A-One-L;Azolmen;Bedriol;Bifazol;bayh4502
CBNumber:
CB8138176
Molecular Formula:
C22H18N2
Molecular Weight:
310.4
MDL Number:
MFCD00865567
MOL File:
60628-96-8.mol
Last updated:2025-07-29 21:08:05

Bifonazole Properties

Melting point 142℃
Boiling point 440.55°C (rough estimate)
Density 1.1150 (rough estimate)
refractive index 1.7620 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO
form powder
pka 6.55±0.22(Predicted)
color white to off-white
Merck 14,1213
InChI InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
InChIKey OCAPBUJLXMYKEJ-UHFFFAOYSA-N
SMILES C(C1C=CC=CC=1)(N1C=NC=C1)C1C=CC(C2C=CC=CC=2)=CC=1
LogP 4.770
CAS DataBase Reference 60628-96-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII QYJ305Z91O
ATC code D01AC10,D01AC60
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  1
RTECS  NI3517000
HS Code  29332900
Toxicity LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)
NFPA 704
0
1 0

Bifonazole price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001421 Bifonazole for system suitability European Pharmacopoeia (EP) Reference Standard 60628-96-8 10 mg $228 2025-07-31 Buy
Sigma-Aldrich B3563 Bifonazole ≥98% (HPLC) 60628-96-8 10mg $55.8 2025-07-31 Buy
Sigma-Aldrich B3563 Bifonazole ≥98% (HPLC) 60628-96-8 50mg $214 2025-07-31 Buy
Sigma-Aldrich B1110000 Bifonazole European Pharmacopoeia (EP) Reference Standard 60628-96-8 50 mg $159 2025-07-31 Buy
TCI Chemical B4173 Bifonazole >98.0%(GC)(T) 60628-96-8 1g $34 2025-07-31 Buy
Product number Packaging Price Buy
Y0001421 10 mg $228 Buy
B3563 10mg $55.8 Buy
B3563 50mg $214 Buy
B1110000 50 mg $159 Buy
B4173 1g $34 Buy

Bifonazole Chemical Properties,Uses,Production

Description

Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.

Description

Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria. It is effective in the treatment of experimental dermatophytic and Candida in animals. Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM), which catalyzes the biosynthesis of estrogens from androgens. When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.

Chemical Properties

White or almost white, crystalline powder.

Originator

Bayer (W. Germany)

Uses

antibacterial

Uses

Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.

Definition

ChEBI: 1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of imidazoles and a member of biphenyls.

Manufacturing Process

38.8g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol and 39 (0.075 mol) of sodium borohydride are added. After heating for 15 hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed with water containing a little hydrochloric acid. The solid thereby produced is purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl- 4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α- (biphenyl-4-yl)benzylalcohol] of melting point 72°-73°C are obtained.
13.6 g (0.2 mol) of imidazole are dissolved in 150 ml of acetonitrile and 3.5 ml of thionyl chloride are added at 10°C. 13 g (0.05 mol) of (biphenyl-4-yl)- phenyl-carbinol are added to the solution of thionyl-bis-imidazole thus obtained. After standing for 15 hours at room temperature, the solvent is removed by distillation in vacuo. The residue is taken up in chloroform and the solution is washed with water. The organic phase is collected, dried over sodium sulfate and filtered and the solvent is distilled off in vacuo. The oily residue is dissolved in ethyl acetate and freed from insoluble, resinous constituents by filtration. The solvent is again distilled off in vacuo and the residue is purified by recrystallization from acetonitrile, 8.7 g (56% of theory) of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane [alternatively named as diphenyl-imidazolyl-(1)-phenyl-methane or as 1-(α-biphenyl-4- ylbenzyl)imidazole] of melting point 142°C are obtained.

brand name

Mycospor (Bayer).

Therapeutic Function

Antifungal

288-32-4
613-42-3
60628-96-8
Synthesis of Bifonazole from Imidazole and 4-BENZYLBIPHENYL
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  • Mar 16，2024

View Lastest Price from Bifonazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bifonazole pictures 2025-08-08 Bifonazole
60628-96-8
 US $0.00 / Kg/Drum 1KG 98%-100.5% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
bifonazole pictures 2025-08-08 bifonazole
60628-96-8
 US $0.00 / KG 1ASSAYS 99% 100000month/kg Hebei Mujin Biotechnology Co.,Ltd
Bifonazole pictures 2025-07-29 Bifonazole
60628-96-8
 US $31.00 / g 99.87% 10g TargetMol Chemicals Inc.
  • Bifonazole pictures
  • Bifonazole
    60628-96-8
  • US $0.00 / Kg/Drum
  • 98%-100.5%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • bifonazole pictures
  • bifonazole
    60628-96-8
  • US $0.00 / KG
  • 99%
  • Hebei Mujin Biotechnology Co.,Ltd
  • Bifonazole pictures
  • Bifonazole
    60628-96-8
  • US $31.00 / g
  • 99.87%
  • TargetMol Chemicals Inc.

Bifonazole Spectrum

Bifonazole for system suitability Bifonazole Impurity Biphenylylbenzylazole trifonazole 1-[P,ALPHA-DIPHENYLBENZYL]IMIDAZOLE 1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE BIFONAZOLE 1-(p,α-diphenylbenzyl)imidazole BIFONAZOLE(PATENT-NOSUPPLY) 1-[α-(4-biphenyl)benzyl]-1H-imidazole 1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)- Amycor A-One-L Azolmen Bedriol Bifazol 1-((1,1’-biphenyl)-4-ylphenylmethyl)-1h-imidazol 1-((4-biphenylyl)phenylmethyl)-1h-imidazole 1-(alpha-(4-biphenylyl)benzyl)-imidazol 1-(alpha-(4-biphenylyl)benzyl)imidazole 1-[(1,1’-biphenyl)-4-ylphenylmethyl]-1H-Imidazole bayh4502 Mycosporan Bedrid 1-[α-(4-Biphenylyl)benzyl]-1H-imidazole Bifonazole API Bifonazole, >=98% (HPLC) 1-(Biphenyl-4-yl(Phenyl)Methyl)-1H-Imidazole 1-(alpha,4-Diphenylbenzyl)imidazole Bifonazole USP/EP/BP BifonazoleQ: What is Bifonazole Q: What is the CAS Number of Bifonazole Q: What is the storage condition of Bifonazole Q: What are the applications of Bifonazole Naftifine hydrochloride Solution, 100ppm Bifonazole > Bifonazole for system suitability CRS Bifonazole CRS bifonazol 1-[phenyl-(4-phenylphenyl)-methyl]imidazole mycospor Bifonazole,NA,Pregabalin 1-([1,1'-Biphenyl]-4-yl(phenyl)methyl)-1H-imidazole (¨¤)-Bifonazo Bibenzazole Bifonazole, 10 mM in DMSO Bifonazole - Bio-X ? Bifonazole (Bay H-4502) (±)-Bifonazole 60628-96-8 API SARAFLOX