INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2891574-93-7
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- EF-4-177;Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)-
- CBNumber:
- CB813145361
- Molecular Formula:
- C18H13F5N3O2S.H
- Molecular Weight:
- 431.38
- MDL Number:
- MOL File:
- 2891574-93-7.mol
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Uses
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2].
IC 50
CDK2/cyclinE: 87 nM (IC50)
References
[1] Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. DOI:10.1021/acs.jmedchem.2c01731
[2] Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. DOI:10.1016/j.ejmech.2024.116547
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Territorial sea Biological Technology Co., LTD | 15092083467 | 18660263263@163.com | China | 2771 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 25521 | 58 |
| Supplier | Advantage |
|---|---|
| Shandong Territorial sea Biological Technology Co., LTD | 58 |
| TargetMol Chemicals Inc. | 58 |