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ChemicalBook >> CAS DataBase List >>Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-

CAS No.
2375420-34-9
Chemical Name:
Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-
Synonyms
SR-717 free acid;2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoic acid;Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-
CBNumber:
CB78096129
Molecular Formula:
C15H9F2N5O3
Molecular Weight:
345.26
MDL Number:
MFCD34470849
MOL File:
2375420-34-9.mol
Last updated:2025-04-18 09:52:43

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- Properties

form Solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals 020444 SR-717 2375420-34-9 001 $600 2021-12-16 Buy
DC Chemicals 020444 SR-717 2375420-34-9 002 $1000 2021-12-16 Buy
Chemenu CM328819 4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoicacid 95%+ 2375420-34-9 100mg $1748 2021-12-16 Buy
DC Chemicals 020444 SR-717 2375420-34-9 003 $2000 2021-12-16 Buy
Product number Packaging Price Buy
020444 001 $600 Buy
020444 002 $1000 Buy
CM328819 100mg $1748 Buy
020444 003 $2000 Buy

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- Chemical Properties,Uses,Production

Uses

SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].

in vivo

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

Animal Model:WT or Stinggt/gt mice[1]
Dosage:30 mg/kg
Administration:Intraperitoneally; once-per-day for 1 week
Result:Maximally inhibited tumor growth.

References

[1] Emily N Chin, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999. DOI:10.1126/science.abb4255

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- Suppliers

Global( 13)Suppliers
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7972 62
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58
Tianjin heowns Biochemical Technology Co., Ltd. 400-6387771-6039 18920564737 sales@heowns.com China 23634 60
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 971 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 9855 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29784 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7381 58
Shanghai jerryxing Biomedical Technology Co., Ltd 17721492509; 17721492509 643638326@qq.com China 4951 58

2375420-34-9(Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-)Related Search:

Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- SR-717 free acid 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoic acid 2375420-34-9 C15H9F2N5O3