LYSOSTAPHIN
- CAS No.
- 9011-93-2
- Chemical Name:
- LYSOSTAPHIN
- Synonyms
- Ambicin L;LYSOSTAPHIN;EC 3.4.24.75;E.C. 3.4.24.75;Lysostaphin from;LYSOSTAPHIN USP/EP/BP;Lysostaphin (600 U/mg);glycyl-glycine endopeptidase;LYSOSTAPHIN AFFINITY PURIFIED;LYSOSTAPHIN ASEPTICALLY FILLED
- CBNumber:
- CB7415982
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00131556
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | powder |
| color | slightly brown |
| biological source | microbial (Staphylococcus staphylotyticus) |
| Water Solubility | water: 2.00-2.10mg/mL, clear to slightly hazy, colorless to light yellow |
| Merck | 13,5659 |
| Specific Activity | ≥500units/mg protein |
| EWG's Food Scores | 1 |
| FDA UNII | 63R7TZH0UA |
| UNSPSC Code | 12352204 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261-P284-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | OL5985000 |
| F | 10-21 |
| HS Code | 3507909090 |
| Toxicity | LD50 (7-day) in mice, rats (mg/kg): 820, 530 i.v. (Zygmunt) |
LYSOSTAPHIN price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAE0091 | Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500?units/mg protein | 9011-93-2 | 2MG | $236 | 2024-03-01 | Buy |
| Sigma-Aldrich | L4402 | Lysostaphin from Staphylococcus staphylolyticus BioUltra, ≥97% (SDS-PAGE), Protein 40-60?% by biuret, ≥2,000?units/mg protein | 9011-93-2 | 0.5mg | $132.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | L2898 | Lysostaphin from Staphylococcus staphylolyticus aseptically filled | 9011-93-2 | 1mg | $381 | 2024-03-01 | Buy |
| Sigma-Aldrich | SRE0053 | Lysostaphin from Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder | 9011-93-2 | 5mg | $234.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | L7386 | Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein | 9011-93-2 | 1mg | $120 | 2024-03-01 | Buy |
LYSOSTAPHIN Chemical Properties,Uses,Production
Uses
Lysostaphin from Staphylococcus simulans has been used in a study to assess molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. It has also been used in a study to investigate the sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity.
General Description
Chemical structure: peptide
Biochem/physiol Actions
Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic. pH Optimum for activity: ~7.5
in vivo
Lysostaphin (5 mg/kg, intravenous injection, once daily for 3 consecutive days) effectively clears systemic Staphylococcus aureus (MSSA) infections in CF-1 mice[2]. Lysostaphin (50 mg/kg, intravenous injection, single dose) effectively clears Staphylococcus aureus (MSSA and MRSA) infections from the kidneys, spleen, and liver, but is not superior to repeated lower doses[2]. Lysostaphin (1 mg/kg, intravenous injection, once daily for 3 consecutive days) combined with Oxacillin (HY-B0925A) achieves the same antibacterial effect with a lower concentration of Lysostaphin. When combined with Vancomycin, low-dose Lysostaphin (1 mg/kg) similarly shows enhanced efficacy against MRSA[2].
| Animal Model: | Systemic infection model in CF-1 mice induced by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)[2] |
| Dosage: | 1, 5, 25, 50 mg/kg |
| Administration: | Intravenous injection (i.v.), single high-dose administration: 25 mg/kg or 50 mg/kg intravenous injection, single dose; Once daily administration: 1 or 5 mg/kg, once daily for 3 days. |
| Result: | Cleared MSSA from the blood and organs of mice (5 mg/kg for 3 days). Cleared MSSA and MRSA from the kidneys, spleen, and liver (A higher single dose of 50 mg/kg). Improved effectiveness and allowed reduction of the lysostaphin dose to 1 mg/kg for MRSA infections (Combined with Oxacillin (HY-B0925A) or Vancomycin (HY-B0671)). |
LYSOSTAPHIN Preparation Products And Raw materials
Raw materials
Preparation Products
LYSOSTAPHIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5935 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20203 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32361 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22729 | 58 |
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | doris@njduly.com | China | 2448 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from LYSOSTAPHIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-21 | Lysostaphin
9011-93-2
|
US $0.00-0.00 / g | 1g | 98.0% | 1kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-07-09 | Lysostaphin
9011-93-2
|
US $89.00-455.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-03-29 | LYSOSTAPHIN
9011-93-2
|
US $6.00-0.20 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- Lysostaphin
9011-93-2
- US $0.00-0.00 / g
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Lysostaphin
9011-93-2
- US $89.00-455.00 / mg
- TargetMol Chemicals Inc.
-
- LYSOSTAPHIN
9011-93-2
- US $6.00-0.20 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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