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ChemicalBook >> CAS DataBase List >>2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

CAS No.
811811-33-3
Chemical Name:
2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-
Synonyms
EMD 495235;2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3;5-chloro-N-[(2R)-3-methoxy-1-[3-methyl-4-(3-oxomorpholin-4-yl)anilino]-1-oxopropan-2-yl]thiophene-2-carboxamide;2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-
CBNumber:
CB71871857
Molecular Formula:
C20H22ClN3O5S
Molecular Weight:
451.92
MDL Number:
MFCD11656013
MOL File:
811811-33-3.mol
Last updated:2025-04-18 09:52:40

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation CCH0013002 5-CHLORO-N-[(1R)-1-(METHOXYMETHYL)-2-[[3-METHYL-4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]-2-OXOETHYL]-2-THIOPHENECARBOXAMIDE 95.00% 811811-33-3 5MG $504.81 2021-12-16 Buy
Product number Packaging Price Buy
CCH0013002 5MG $504.81 Buy

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- Chemical Properties,Uses,Production

Uses

EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities[1].

in vivo

EMD 495235 is characterized by rapid absorption from the gastrointestinal tract, plasma elimination half-lives of 0.57-2.3 h, a clearance between 0.25 and 1.3L/h/kg and absolute bioavailability of 60-80% in Wistar rats, Beagle dogs and Cynomolgus monkeys[1].

References

[1] Werner W K R Mederski, et al. Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5817-22. DOI:10.1016/j.bmcl.2004.09.043

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Henan CoreyChem Co., Ltd 0371-86658258 info@coreychem.com China 10453 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26070 58
2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- 2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3 5-chloro-N-[(2R)-3-methoxy-1-[3-methyl-4-(3-oxomorpholin-4-yl)anilino]-1-oxopropan-2-yl]thiophene-2-carboxamide EMD 495235 811811-33-3