2-BROMO-4-FLUORO-6-NITROANILINE
- CAS No.
- 10472-88-5
- Chemical Name:
- 2-BROMO-4-FLUORO-6-NITROANILINE
- Synonyms
- SKL366;2-BROMO-4-FLUORO-6-NITROANILINE;2-Bromo-4-fluoro-6-nitroaniline98%;2-Bromo-4-fluoro-6-nitroaniline 98%;2-bromo-4-fluoro-6-nitrobenzenamine;2-Bromo-4-fluoro-6-nitroaniline, 97%;2-Amino-3-bromo-5-fluoronitrobenzene;BenzenaMine, 2-broMo-4-fluoro-6-nitro-;2-Bromo-4-fluoro-6-nitroaniline,tech.90%;Benzenebutanoicacid,7-fluoro-α,γ-dioxo-,ethylester
- CBNumber:
- CB7159910
- Molecular Formula:
- C6H4BrFN2O2
- Molecular Weight:
- 235.01
- MDL Number:
- MFCD07779528
- MOL File:
- 10472-88-5.mol
- MSDS File:
- SDS
| Melting point | 70-72°C |
|---|---|
| Boiling point | 313.9±37.0 °C(Predicted) |
| Density | 1.896±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Powder |
| pka | -2.32±0.25(Predicted) |
| color | Orange |
| InChI | InChI=1S/C6H4BrFN2O2/c7-4-1-3(8)2-5(6(4)9)10(11)12/h1-2H,9H2 |
| InChIKey | HCYDUPDSEDHSQB-UHFFFAOYSA-N |
| SMILES | C1(N)=C([N+]([O-])=O)C=C(F)C=C1Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | T | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2921420090 | |||||||||
| NFPA 704 |
|
2-BROMO-4-FLUORO-6-NITROANILINE price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4872 | 2-Bromo-4-fluoro-6-nitroaniline >98.0%(GC) | 10472-88-5 | 1g | $118 | 2025-07-31 | Buy |
| TRC | B679175 | 2-Bromo-4-fluoro-6-nitroaniline | 10472-88-5 | 250mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-W001097 | 2-Bromo-4-fluoro-6-nitroaniline | 10472-88-5 | 5g | $40 | 2021-12-16 | Buy |
| AK Scientific | X8725 | 2-Bromo-4-fluoro-6-nitroaniline | 10472-88-5 | 1g | $70 | 2021-12-16 | Buy |
| Matrix Scientific | 081208 | 2-Bromo-4-fluoro-6-nitroaniline 97% | 10472-88-5 | 1g | $76 | 2021-12-16 | Buy |
2-BROMO-4-FLUORO-6-NITROANILINE Chemical Properties,Uses,Production
Chemical Properties
off-white powder
Uses
2-Bromo-4-fluoro-6-nitroaniline is used as pharmaceutical intermediate.
Synthesis
364-78-3
10472-88-5
The general procedure for the synthesis of 2-bromo-4-fluoro-6-nitroaniline from 4-fluoro-2-nitroaniline is as follows: 1. 4-fluoro-2-nitroaniline (10.0 g, 42.55 mmol) was dissolved in dichloromethane (DCM) to prepare a mixture. 2. a mixture of bromine (Br2, 9.9 ml, 130 mmol) in dichloromethane (110 mL, pre-cooled to 0 °C) and acetic acid (HOAc, 75 mL) was slowly added dropwise at 0 °C, with the rate of dropwise acceleration being controlled to keep the internal reaction temperature below 10 °C. 3. After titration, the reaction mixture was stirred at room temperature overnight. 4. The reaction mixture was poured into water (500 mL) to separate the organic phase. 5. The pH of the aqueous phase was adjusted to about 7 with ammonium hydroxide (NH4OH) and then the aqueous phase was extracted with dichloromethane (DCM, 100 mL x 3). 6. The organic extracts were combined, dried with magnesium sulfate (MgSO4), filtered and concentrated in vacuum to give 2-bromo-4-fluoro-6-nitroaniline as a yellow solid (14 g, 93% yield). Mass spectrum (ESI): m/z = 233 [M-1].
References
[1] Patent: US5606063, 1997, A
[2] Patent: WO2013/26914, 2013, A1. Location in patent: Page/Page column 118
[3] Patent: CN108218887, 2018, A. Location in patent: Paragraph 0094; 0097; 0098; 0099
[4] Journal of Antibiotics, 1994, vol. 47, # 12, p. 1456 - 1465
[5] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 25
2-BROMO-4-FLUORO-6-NITROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1382 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 2-BROMO-4-FLUORO-6-NITROANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-26 | 2-BROMO-4-FLUORO-6-NITROANILINE
10472-88-5
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-11-15 | 2-Bromo-4-fluoro-6-n
10472-88-5
|
US $10.00 / KG | 1KG | 99% | 500ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2020-02-26 | 2-Bromo-4-fluoro-6-nitroaniline
10472-88-5
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-BROMO-4-FLUORO-6-NITROANILINE
10472-88-5
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Bromo-4-fluoro-6-n
10472-88-5
- US $10.00 / KG
- 99%
- Qiuxian Baitai New Material Co., LTD
-
- 2-Bromo-4-fluoro-6-nitroaniline
10472-88-5
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
