694466-00-7
- CAS No.
- 694466-00-7
- Chemical Name:
- 694466-00-7
- Synonyms
- WAY-324883;hCAI/II-IN-6;2-(4-Benzylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide;1-Piperazineacetamide, N-[4-(aminosulfonyl)phenyl]-4-(phenylmethyl)-
- CBNumber:
- CB711174689
- Molecular Formula:
- C19H24N4O3S
- Molecular Weight:
- 388.48
- MDL Number:
- MOL File:
- 694466-00-7.mol
694466-00-7 Chemical Properties,Uses,Production
Description
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ??50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].
hCAI/II-IN-6 (0-50 μM) inhibits hCA I, hCA II , hCA VII and hCA XII activities with Ki values of 220, 4.9, 6.5 and ??50000 nM, respectively[1].
hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo[1].
hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo[1].
Uses
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].
in vivo
hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo[1]. hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo[1].
| Animal Model: | Swiss albino mice[1] |
| Dosage: | 30 and 100 mg/kg |
| Administration: | Intraperitoneal injection; 30-100 mg/kg once |
| Result: | Provided seizure attenuation and good anticonvulsant effect, and showed an ED50 of 13.7mg/kg in anticonvulsant quantification study. |
| Animal Model: | Wistar albino rats[1] |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage; 30 mg/kg once |
| Result: | Showed anti-MES activity and significant protection from seizures up to 1h of drug administration and action was gone reduced after 1h. |
References
[1] Mishra CB, et al. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. J Med Chem. 2017 Mar 23;60(6):2456-2469. DOI:10.1021/acs.jmedchem.6b01804
694466-00-7 Preparation Products And Raw materials
Raw materials
Preparation Products
694466-00-7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6711 | 55 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4913 | 55 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4775 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 48457 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
