Lorigerlimab
- CAS No.
- 2416595-46-3
- Chemical Name:
- Lorigerlimab
- Synonyms
- Lorigerlimab;Research Grade Lorigerlimab;Research Grade Lorigerlimab (DHD17208)
- CBNumber:
- CB710617086
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | JM802R57SA |
|---|
Lorigerlimab Chemical Properties,Uses,Production
Uses
Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3].
in vivo
Lorigerlimab (75 mg/kg, i.v.) shows CTLA-4 blockade in in cynomolgus monkeys[2].
Lorigerlimab (10-100 mg/kg, i.v., 4 weeks) is well tolerated in cynomolgus monkeys, and shows a half-life about 7 days[2].
| Animal Model: | Cynomolgus monkeys [4] |
| Dosage: | 75 mg/kg |
| Administration: | i.v. |
| Result: | Increased the Ki67+ T cell fraction, and showed T cell expansion in the spleen. |
References
[1] Jason J. Luke, et al. Lorigerlimab, a bispecific PD-1×CTLA-4 DART molecule in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): A phase 1 expansion (exp) cohort. Journal of Clinical Oncology 2023 41:6_suppl, 155-155.
[2] Berezhnoy A, et al. Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 Dec 22;1(9):100163. DOI:10.1016/j.xcrm.2020.100163
[3] Trojaniello C, Luke JJ, Ascierto PA. Therapeutic Advancements Across Clinical Stages in Melanoma, With a Focus on Targeted Immunotherapy. Front Oncol. 2021 Jun 10;11:670726. DOI:10.3389/fonc.2021.670726
Lorigerlimab Preparation Products And Raw materials
Raw materials
Preparation Products
Lorigerlimab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7972 | 62 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| Biolab Reagents | 18108604356 | info@biolabreagent.com | China | 9868 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6216 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 13823398779 | 3062105966@qq.com | China | 3452 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9914 | 58 |
| AntibodySystem Laboratories SAS | 33175446423 | support@antibodysystem.com | China | 6739 | 58 |
| Cell Sciences | 9785721070 | info@cellsciences.com | China | 6308 | 58 |
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