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ChemicalBook >> CAS DataBase List >>1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)-

1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)-

CAS No.
1816272-19-1
Chemical Name:
1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)-
Synonyms
(R,R)-GSK321;WT IDH1 Inhibitor 2;1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)-
CBNumber:
CB69768569
Molecular Formula:
C28H28FN5O3
Molecular Weight:
501.55
MDL Number:
MOL File:
1816272-19-1.mol
Last updated:2025-04-29 09:03:59

1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- Properties

Boiling point 704.2±60.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.26±0.70(Predicted)
form Solid
color White to off-white

1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- Chemical Properties,Uses,Production

Uses

(R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. (R,R)-GSK321 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

Biological Activity

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1]. WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

IC 50

IDH1

References

[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19930 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 25122 58

View Lastest Price from 1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WT IDH1 Inhibitor 2 pictures 2025-04-29 WT IDH1 Inhibitor 2
1816272-19-1
 US $1990.00 / mg 10g TargetMol Chemicals Inc.
1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- WT IDH1 Inhibitor 2 (R,R)-GSK321 1816272-19-1