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ChemicalBook >> CAS DataBase List >>Pactimibe sulfate

Pactimibe sulfate

CAS No.
608510-47-0
Chemical Name:
Pactimibe sulfate
Synonyms
CS505 sulfate;CS-505 sulfate;CS 505 sulfate;Pactimibe sulfate;2-(4,6-Dimethyl-1-octyl-7-pivalamidoindolin-5-yl)acetic acid sulfate(2:1);(7-(2,2-Dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl)acetic acid hemisulfate
CBNumber:
CB69272954
Molecular Formula:
C25H42N2O7S
Molecular Weight:
514.68
MDL Number:
MFCD09832640
MOL File:
608510-47-0.mol
Last updated:2025-04-17 18:22:24

Pactimibe sulfate Properties

Melting point 167-169 °C(Solv: ethanol (64-17-5); water (7732-18-5))
storage temp. 4°C, away from moisture
solubility DMSO : 120 mg/mL (257.70 mM)
form Solid
color Off-white to gray
FDA UNII FX3YKK43YM

Pactimibe sulfate Chemical Properties,Uses,Production

Uses

Pactimibe Sulfate (2:1) is an impurity of Pactimibe(189198-30-9) and can be used to prepare oral pharmaceuticals microspheres.

in vivo

Pactimibe sulfate (CS-505; 60 and 200 mg/kg/day; oral gavage; twice a day; 12 weeks) induces an inhibition for ACAT-1 and ACAT-2, causing a reduction of plasma cholesterol but no influence on macrophage- or collagen-positive areas[3].

Animal Model:Male C57BL/6J ApoE?/? mice aged 8-week-old[3]
Dosage:60 and 200 mg/kg/day
Administration:Oral gavage; twice a day; 12 weeks
Result:Decreased plasma cholesterol levels by 39% and 74% at the administration of 60 and 200 mg/kg/day.

IC 50

ACAT1: 4.9 μM (IC50); ACAT2: 3.0 μM (IC50); ACAT: 2 μM (IC50, in the liver); ACAT: 2.7 μM (IC50, in macrophages); ACAT: 4.7 μM (IC50, in THP-1 cells); oleoyl-CoA: 5.6 μM (Ki); cholesteryl ester formation: 6.7 μM (IC50)

Pactimibe sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Pactimibe sulfate Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19929 58
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 5003 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7991 62
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9343 58
Shanghai SPAR pharmaceutical technology co., LTD 021-000000 13917643586; admin@jingshipharmatech.com China 9910 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29770 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2380 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24980 58
Shanghai jerryxing Biomedical Technology Co., Ltd 17721492509; 17721492509 643638326@qq.com China 4949 58

View Lastest Price from Pactimibe sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pactimibe sulfate pictures 2025-04-30 Pactimibe sulfate
608510-47-0
 US $1620.00-2110.00 / mg 10g TargetMol Chemicals Inc.
Pactimibe sulfate CS 505 sulfate CS505 sulfate CS-505 sulfate (7-(2,2-Dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl)acetic acid hemisulfate 2-(4,6-Dimethyl-1-octyl-7-pivalamidoindolin-5-yl)acetic acid sulfate(2:1) 608510-47-0