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ChemicalBook >> CAS DataBase List >>(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol

(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol

CAS No.
2408840-26-4
Chemical Name:
(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol
Synonyms
LY-3484356;Imlunestrant;3-c]quinolin-2-ol;Imlunestrant(LY-3484356);(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4;(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol;5H-[1]Benzopyrano[4,3-c]quinolin-2-ol, 5-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-8-(trifluoromethyl)-, (5R)-
CBNumber:
CB68231662
Molecular Formula:
C29H24F4N2O3
Molecular Weight:
524.51
MDL Number:
MOL File:
2408840-26-4.mol
Last updated:2025-04-28 21:36:36

(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol Properties

Boiling point 682.9±55.0 °C(Predicted)
Density 1.360±0.06 g/cm3(Predicted)
pka 8.57±0.40(Predicted)
form Solid
color Light yellow to yellow
FDA UNII 9CXQ3PF69U

(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol Chemical Properties,Uses,Production

Uses

Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

References

[1] Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I.
[2] Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.

(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 310 55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 17702719238 sales@sun-shinechem.com China 1040 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3475 58
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3904 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 596 55
Jinan Kabotang Biological Technology Co.,Ltd. 0531-61320525 15866703830 figo.gao@foxmail.com China 4534 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24899 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5530 58

View Lastest Price from (R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Imlunestrant pictures 2025-04-28 Imlunestrant
2408840-26-4
 US $2140.00-3520.00 / mg 10g TargetMol Chemicals Inc.
  • Imlunestrant pictures
  • Imlunestrant
    2408840-26-4
  • US $2140.00-3520.00 / mg
  • TargetMol Chemicals Inc.
(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol 5H-[1]Benzopyrano[4,3-c]quinolin-2-ol, 5-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-8-(trifluoromethyl)-, (5R)- LY-3484356 Imlunestrant (R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4 3-c]quinolin-2-ol Imlunestrant(LY-3484356) 2408840-26-4 C29H24F4N2O3