LUT-014
- CAS No.
- 2274819-46-2
- Chemical Name:
- LUT-014
- Synonyms
- LUT-014;LUT014, 10 mM in DMSO;LUT014;LUT-014;LUT 014;LUT014,inhibit,Inhibitor,LUT-014,Raf,Raf kinases,LUT 014;6-methyl-N5-[3-(7H-purin-6-yl)pyridin-2-yl]-N1-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine;N5-(3-(7H-Purin-6-yl)pyridin-2-yl)-6-methyl-N1-(3-(trifluoromethoxy)phenyl)isoquinoline-1,5-diamine;1,5-Isoquinolinediamine, 6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-N1-[3-(trifluoromethoxy)phenyl]-
- CBNumber:
- CB64857301
- Molecular Formula:
- C27H19F3N8O
- Molecular Weight:
- 528.49
- MDL Number:
- MFCD32062738
- MOL File:
- 2274819-46-2.mol
| storage temp. | 4°C, protect from light |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | T4E4I523RY |
LUT-014 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0094163 | LUT014 97.19% | 2274819-46-2 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0094163 | LUT014 97.19% | 2274819-46-2 | 10mg | $350 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009827 | LUT-014 95.00% | 2274819-46-2 | 5MG | $454.39 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573430 | LUT014 | 2274819-46-2 | 100mg | $1133.9 | 2021-12-16 | Buy |
| ChemScene | CS-0094163 | LUT014 97.19% | 2274819-46-2 | 50mg | $1200 | 2021-12-16 | Buy |
LUT-014 Chemical Properties,Uses,Production
Uses
LUT014 is a topical inhibitor targeting BRAF that cannot pass through the blood-brain barrier. LUT014 inhibits BRAF kinase and abnormally activates the MAPK/ERK signaling pathway, promoting the proliferation of epidermal keratinocytes, repairing skin barrier damage caused by radiation damage, and alleviating inflammatory responses. LUT014 is independent of RAS signaling and accelerates the repair and regeneration of damaged skin cells. LUT014 can be used to study radiation dermatitis, especially skin damage caused by breast cancer radiotherapy[1][2][3].
IC 50
B-Raf: 11.7 nM (IC50)
References
[1] Katz S, et al. A topical BRAF inhibitor (LUT-014) for treatment of radiodermatitis among women with breast cancer. JAAD Int. 2023 Dec 25;15:62-68. DOI:10.1016/j.jdin.2023.11.009
[2] Wang PP, et al. BRAF Mutations in Colorectal Liver Metastases: Prognostic Implications and Potential Therapeutic Strategies. Cancers (Basel). 2022 Aug 23;14(17):4067. DOI:10.3390/cancers14174067
[3] Li Y, et al. Mechanism of Lethal Skin Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors and Related Treatment Strategies. Front Oncol. 2022 Feb 10;12:804212. DOI:10.3389/fonc.2022.804212
LUT-014 Preparation Products And Raw materials
Raw materials
Preparation Products
LUT-014 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32364 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1041 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4645 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7992 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9343 | 58 |