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ChemicalBook >> CAS DataBase List >>DECAMETHONIUM BROMIDE

DECAMETHONIUM BROMIDE

CAS No.
541-22-0
Chemical Name:
DECAMETHONIUM BROMIDE
Synonyms
decacuran;syncurine;dekamethoniumbromid;DECAMETHONIUM BROMIDE;decamethoniumdibromide;Decamethonium Bromide >Decamethonium bromide ,98%;Decamethonium Bromide, ≥ 98.0%;DECAMETHONIUM BROMIDE USP/EP/BP;Decamethonium bromide, 10 mM in DMSO
CBNumber:
CB6360047
Molecular Formula:
C16H38Br2N2
Molecular Weight:
418.29
MDL Number:
MFCD00011779
MOL File:
541-22-0.mol
MSDS File:
SDS
Last updated:2025-08-20 16:56:22

DECAMETHONIUM BROMIDE Properties

Melting point 263-267 °C(lit.)
storage temp. Inert atmosphere,Room Temperature
solubility DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
form crystalline
color off-white
Water Solubility almost transparency
λmax λ: 240 nm Amax: 0.04
λ: 250 nm Amax: 0.03
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02
Merck 14,2847
BRN 3728288
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 541-22-0(CAS DataBase Reference)
FDA UNII 55C6RK944K
EPA Substance Registry System Decamethonium dibromide (541-22-0)
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  BP5950000
F  3-10
HS Code  2923.90.0100
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 oral in mouse: 190mg/kg
NFPA 704
0
2 0

DECAMETHONIUM BROMIDE price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1260 Decamethonium bromide crystalline 541-22-0 5g $133 2025-07-31 Buy
Sigma-Aldrich D1260 Decamethonium bromide crystalline 541-22-0 10g $246 2025-07-31 Buy
TCI Chemical D1314 Decamethonium Bromide >98.0%(T) 541-22-0 5g $97 2025-07-31 Buy
TCI Chemical D1314 Decamethonium Bromide >98.0%(T) 541-22-0 25g $292 2025-07-31 Buy
Cayman Chemical 24907 Decamethonium (bromide) ≥98% 541-22-0 1g $32 2024-03-01 Buy
Product number Packaging Price Buy
D1260 5g $133 Buy
D1260 10g $246 Buy
D1314 5g $97 Buy
D1314 25g $292 Buy
24907 1g $32 Buy

DECAMETHONIUM BROMIDE Chemical Properties,Uses,Production

Description

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.

Chemical Properties

crystalline solid

Uses

antipsychotic

brand name

Syncurine (GlaxoSmithKline).

Biological Functions

Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.

General Description

Crystals derived from methanol and acetone.

Air & Water Reactions

Water soluble.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.

Fire Hazard

Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

References

[1] W. D. M. PATON  Eleanor J Z. The action of d-tubocurarine and of decamethonium on respiratory and other muscles in the cat[J]. Journal of Physiology-London, 1951, 112 3-4: 311-331. DOI: 10.1113/jphysiol.1951.sp004531
[2] ROGER L PAPKE J A S Lynn Wecker. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 333 2: 501-518. DOI: 10.1124/jpet.109.164566
[3] J BREK EATON. Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.[J]. Molecular Pharmacology, 2003, 64 6: 1283-1294. DOI: 10.1124/mol.64.6.1283
[4] B ROBAIRE  G K. Effects of edrophonium, eserine, decamethonium, d-tubocurarine, and gallamine on the kinetics of membrane-bound and solubilized eel acetylcholinesterase.[J]. Molecular Pharmacology, 1975, 11 6: 722-734.

DECAMETHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 128)Suppliers
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career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29803 58
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InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
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GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49982 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58

View Lastest Price from DECAMETHONIUM BROMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Decamethonium bromide pictures 2025-07-29 Decamethonium bromide
541-22-0
 US $45.00 / mg 99.90% 10g TargetMol Chemicals Inc.
Decamethonium bromide pictures 2025-07-15 Decamethonium bromide
541-22-0
 US $45.00 / mg 99.90% 10g TargetMol Chemicals Inc.
Decamethonium bromide pictures 2025-04-27 Decamethonium bromide
541-22-0
 US $45.00 / mg 99.79% 10g TargetMol Chemicals Inc.
1,10-Decanediaminium,N,N,N,N’,N’,N’-hexamethyl-,dibromide 10-decanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide decacuran decamethoniumdibromide decamethylene-1,10-bistrimethylammoniumdibromide decamethylenebis(trimethyl-ammoniudibromide 1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2) dekamethoniumbromid DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE) DECAMETHONIUM BROMIDE DECAMETHYLENEBIS[TRIMETHYL-AMMONIUM BROMIDE] syncurine DECAMETHONIUM BROMIDE, FOR ION PAIR CHRO MATOGRAPHY 1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, monobromide Ammonium, decamethylenebis[trimethyl-, dibromide Decamethonium bromide ,98% N1,N1,N1,N10,N10,N10-hexaMethyldecane-1,10-diaMiniuM broMide Decamethylene bis(trimethylammonium bromide), Decane-1,10-bis(trimethylammonium bromide) Decamethonium Bromide > DECAMETHONIUM BROMIDE USP/EP/BP Decamethonium (Bromide)(Reagent for Ion-Pair Chromatography,99%) nAChR,Decamethonium bromide,inhibit,Inhibitor,Decamethonium,Nicotinic acetylcholine receptors Decamethonium Bromide, ≥ 98.0% Decamethonium bromide, 10 mM in DMSO 541-22-0 C16H38N22Br CH33NBrCH210NBrCH33 C16H38Br2N2 C16H38N2Br2 Br2C16H38N2 Analytical Chromatography Product Catalog BioChemical Ammonium Salts Cell Biology Cell Signaling and Neuroscience Ion Channels Nicotinic Acetylcholine Receptor Modulators Phase Transfer Catalysts Synthetic Reagents Quaternary Ammonium Compounds Ammonium Bromides (Quaternary) HPLC Ligand-Gated Ion Channels Ion Pair Reagents - Anionic Ion Pair Reagents IMPROMEN Ammonium Bromides (Quaternary) Quaternary Ammonium Compounds