N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos
- CAS No.
- 1817735-42-4
- Chemical Name:
- N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos
- Synonyms
- Tos-aminoxy-Boc-PEG4-Tos;N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos
- CBNumber:
- CB63363977
- Molecular Formula:
- C27H39NO11S2
- Molecular Weight:
- 617.73
- MDL Number:
- MFCD29042369
- MOL File:
- 1817735-42-4.mol
N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos Chemical Properties,Uses,Production
Description
N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos is a PEG linker containing tosyl, boc and aminoxy moieties. Tosyl is a good leaving group and can also act as an alcohol protecting group in organic synthesis. The t-Boc protecting group can be removed under acidic conditions which allows for the amine group to be further reacted. The hydrophilic PEG linker increases the water solubility of the compound to further enhance the water solubility of the compound in aqueous media.
Uses
Tos-aminoxy-Boc-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos Preparation Products And Raw materials
Raw materials
Preparation Products
N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32354 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9534 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Shanghai Easy CDMO Co.,Ltd | 021-61734564 13854185395; | info@easycdmo.com | China | 10030 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 28728 | 58 |