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ChemicalBook >> CAS DataBase List >>Ethyl 4,6-dichloropyrridazine-3-carboxylate

Ethyl 4,6-dichloropyrridazine-3-carboxylate

CAS No.
679406-03-2
Chemical Name:
Ethyl 4,6-dichloropyrridazine-3-carboxylate
Synonyms
4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester;EOS-61510;4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE;Ethyl 4,6-dichloro-3-pyridazinecarboxylate;Ethyl 4,6-dichloropyrridazine-3-carboxylate;4,6-Dichloropyrazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylic acid, 4,6-dichloro-, ethyl ester
CBNumber:
CB62461124
Molecular Formula:
C7H6Cl2N2O2
Molecular Weight:
221.04
MDL Number:
MFCD11521570
MOL File:
679406-03-2.mol
MSDS File:
SDS
Last updated:2023-07-03 17:51:04

Ethyl 4,6-dichloropyrridazine-3-carboxylate Properties

Boiling point 353.4±37.0 °C(Predicted)
Density 1.433±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Acetonitrile (Slightly), Chloroform (Soluble), Methanol (Slightly)
pka -2.18±0.10(Predicted)
form Low-Melting Solid
color Brown to Very Dark Brown

Ethyl 4,6-dichloropyrridazine-3-carboxylate price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC E903353 ethyl4,6-dichloropyridazine-3-carboxylate 679406-03-2 2.5mg $45 2021-12-16 Buy
ChemScene CS-W022681 Ethyl4,6-dichloropyridazine-3-carboxylate 97.15% 679406-03-2 1g $96 2021-12-16 Buy
AK Scientific W7825 Ethyl4,6-dichloropyridazine-3-carboxylate 679406-03-2 1g $262 2021-12-16 Buy
ChemScene CS-W022681 Ethyl4,6-dichloropyridazine-3-carboxylate 97.15% 679406-03-2 5g $270 2021-12-16 Buy
ChemScene CS-W022681 Ethyl4,6-dichloropyridazine-3-carboxylate 97.15% 679406-03-2 10g $450 2021-12-16 Buy
Product number Packaging Price Buy
E903353 2.5mg $45 Buy
CS-W022681 1g $96 Buy
W7825 1g $262 Buy
CS-W022681 5g $270 Buy
CS-W022681 10g $450 Buy

Ethyl 4,6-dichloropyrridazine-3-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 4,6-Dichloropyridazine-3-carboxylate is a useful reagent for the green preparation of Deucravacitinib, a deuterated API for TYK2 Inhibition.

Synthesis

To a 350 mL nitrogen purged Schlenk flask containing Ethyl 4,6-dihydroxypyridazine-3-carboxylate (3.77 g, 20.47 mmol) was added phosphorus oxychloride (38 mL, 408 mmol). The vessel was sealed and heated to 100 °C for 3.5 hours. The reaction was cooled to room temperature and the excess phosphorus oxychloride was removed in vacuo. The crude oil was dissolved into chloroform, re-concentrated and then poured into ice water, rinsing with ethyl acetate.The two layers were transferred to a separatory funnel, separated and the aqueous layer extracted 3x with ethyl acetate. The combined organic layers were washed twice with water and once with brine (saturated aqueous sodium chloride) and then dried over sodium sulfate, filtered, concentrated and then purified by automated chromatography (5- 90percent EtOAc:hexanes), providing Ethyl 4,6-dichloropyrridazine-3-carboxylate (3.64 g, 16.3 mmol). ‘H NMR (400MHz, chloroform-d) ? 7.70 (s, 1H), 4.55 (qd, J=7.1, 1.1 Hz, 2H), 1.46 (td, J=7.2, 0.9 Hz, 3H).
synthesis of Ethyl 4,6-dichloropyrridazine-3-carboxylate

1352925-63-3
679406-03-2
Synthesis of Ethyl 4,6-dichloropyrridazine-3-carboxylate from ethyl 4,6-dihydroxypyridazine-3-carboxylate

Ethyl 4,6-dichloropyrridazine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 148)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1015 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 20103 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12240 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 7933 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5661 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58

View Lastest Price from Ethyl 4,6-dichloropyrridazine-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4,6-dichloropyrridazine-3-carboxylate pictures 2023-11-01 Ethyl 4,6-dichloropyrridazine-3-carboxylate
679406-03-2
 US $0.00-0.00 / kg 1kg 99.0% 20 tons Hangzhou ICH Biofarm Co., Ltd
Ethyl 4,6-dichloropyrridazine-3-carboxylate pictures 2023-02-10 Ethyl 4,6-dichloropyrridazine-3-carboxylate
679406-03-2
 US $0.00-0.00 / kg 1kg In house standard. 1 ton Jiangsu Guotai Guomian Trading Co. Ltd.
ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE pictures 2019-07-10 ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
679406-03-2
 US $1.00 / KG 1KG 98% 150KG Career Henan Chemical Co

679406-03-2(Ethyl 4,6-dichloropyrridazine-3-carboxylate)Related Search:

ETHYL 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE EOS-61510 4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE 3-Pyridazinecarboxylic acid, 4,6-dichloro-, ethyl ester 4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester Ethyl 4,6-dichloropyrridazine-3-carboxylate 4,6-Dichloropyrazine-3-carboxylic acid ethyl ester Ethyl 4,6-dichloro-3-pyridazinecarboxylate 679406-03-2