5-hydroxymethyl-pyrrolidine-2-one
- CAS No.
- 62400-75-3
- Chemical Name:
- 5-hydroxymethyl-pyrrolidine-2-one
- Synonyms
- pyroglutamol;DL-Pyroglutaminol;5-hydroxymethyl-pyrrolidine-2-one;2-Pyrrolidinone,5-(hydroxyMethyl)-;5-(HYDROXYMETHYL)PYRROLIDIN-2-ONE(WX640368);(5S)-5-(hydroxyMethyl)tetrahydro-1H-2-pyrrolone
- CBNumber:
- CB61459061
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD06661931
- MOL File:
- 62400-75-3.mol
- MSDS File:
- SDS
| Melting point | 87 °C |
|---|---|
| Boiling point | 185-187 °C(Press: 4 Torr) |
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.35±0.10(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | 2.3°(C=0.96 g/100ml ETOH) |
| InChI | InChI=1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8) |
| InChIKey | HOBJEFOCIRXQKH-UHFFFAOYSA-N |
| SMILES | N1C(CO)CCC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
5-hydroxymethyl-pyrrolidine-2-one price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H801600 | 5-(hydroxymethyl)-2-Pyrrolidinone | 62400-75-3 | 100mg | $55 | 2021-12-16 | Buy |
| TRC | H801600 | 5-(hydroxymethyl)-2-Pyrrolidinone | 62400-75-3 | 1g | $250 | 2021-12-16 | Buy |
| Matrix Scientific | 135110 | 5-(Hydroxymethyl)pyrrolidin-2-one 95%+ | 62400-75-3 | 5g | $305 | 2021-12-16 | Buy |
| AK Scientific | 9405AB | 5-(Hydroxymethyl)pyrrolidin-2-one | 62400-75-3 | 5g | $329 | 2021-12-16 | Buy |
| AK Scientific | 9405AB | 5-(Hydroxymethyl)pyrrolidin-2-one | 62400-75-3 | 10g | $529 | 2021-12-16 | Buy |
5-hydroxymethyl-pyrrolidine-2-one Chemical Properties,Uses,Production
Uses
5-(hydroxymethyl)-2-Pyrrolidinone is a building block and an analog of Pramanicin which induces apoptosis in human colon cancer cells. 5-(hydroxymethyl)-2-Pyrrolidinone is also available with specified stereochemistry (P997525, H948310).
Synthesis
4931-66-2
62400-75-3
Methyl 5-oxopyrrolidine-2-carboxylate (9 g, 62.93 mmol) was dissolved in methanol (150 mL) under argon protection, stirred and cooled to 0 °C. Subsequently, sodium borohydride (3.6 g, 95.2 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was quenched with concentrated hydrochloric acid at 0°C. The reaction mixture was filtered and the solid was washed with methanol (2 x 50 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography with 10% methanol/dichloromethane as eluent to give 5-(hydroxymethyl)pyrrolidin-2-one (6 g, 83% yield) as a colorless oil. Liquid chromatography-mass spectrometry (LCMS) analysis showed that the [M+1]+ was 116; chromatographic conditions: X-Select CSH C-18 column (50×3.0 mm, 3.5 μm); mobile phase: 5 mM aqueous ammonium acetate/acetonitrile; flow rate: 0.80 mL/min; retention time (RT): 0.44 min. Thin-layer chromatography (TLC) analysis showed that the unfolding agent was 10% methanol/dichloromethane and the Rf value was 0.3.
References
[1] Patent: WO2015/109109, 2015, A1. Location in patent: Paragraph 1239
[2] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 1804
5-hydroxymethyl-pyrrolidine-2-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
View Lastest Price from 5-hydroxymethyl-pyrrolidine-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | 5-hydroxymethyl-pyrrolidine-2-one
62400-75-3
|
US $1.00 / g | 1g | 99% | 1000KGS | Career Henan Chemical Co |
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- 5-hydroxymethyl-pyrrolidine-2-one
62400-75-3
- US $1.00 / g
- 99%
- Career Henan Chemical Co
