Semorinemab
- CAS No.
- 2159141-27-0
- Chemical Name:
- Semorinemab
- Synonyms
- Semorinemab;Semorinemab (anti-Tau);Research Grade Semorinemab;Research Grade Semorinemab(DHC82404)
- CBNumber:
- CB58081147
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | O8DG8VI95O |
Semorinemab Chemical Properties,Uses,Production
Uses
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].
in vivo
Semorinemab (3, 10 and 30 mg/kg; i.p., once weekly for 13 weeks) reduces accumulation of Tau pathology in a transgenic (Tg) mouse model of tauopathy[1].
| Animal Model: | Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks |
| Result: | Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205. |
References
[1] Ayalon G, et al. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Sci Transl Med. 2021 May 12;13(593):eabb2639. DOI:10.1126/scitranslmed.abb2639
Semorinemab Preparation Products And Raw materials
Raw materials
Preparation Products
Semorinemab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7999 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1566 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| Biolab Reagents | 18108604356 | info@biolabreagent.com | China | 9868 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6220 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 13823398779 | 3062105966@qq.com | China | 3452 | 58 |
| Wanxin Biotechnology (Jiaxing) Co., LTD | 0573-83568680 18057391398 | 3956524501@qq.com | China | 1442 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9914 | 58 |
