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ChemicalBook >> CAS DataBase List >>2-Acetyl-6-bromopyridine

2-Acetyl-6-bromopyridine

CAS No.
49669-13-8
Chemical Name:
2-Acetyl-6-bromopyridine
Synonyms
1-(6-Bromopyridin-2-yl)ethan-1-one;1-(6-Bromopyridine;2-Acetyl-6-bromopyridine;2-Bromo-6-Acetylpyridine;2-Acetyl-6-bromopyridine>2- acetyl-6-pyridyl broMide;2-ACETYL-6-BROMOPYRIDINE 97;2-Acetyl-6-bromopyridine 97%;1-(6-bromo-2-pyridyl)ethanone;1-(6-Brompyridin-2-yl)ethanon
CBNumber:
CB5505252
Molecular Formula:
C7H6BrNO
Molecular Weight:
200.03
MDL Number:
MFCD00272200
MOL File:
49669-13-8.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:49

2-Acetyl-6-bromopyridine Properties

Melting point 51-55 °C (lit.)
Boiling point 271.2±25.0 °C(Predicted)
Density 1.534±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol.
form Solid
pka 0.28±0.10(Predicted)
color Off-White to Pale Beige
InChI InChI=1S/C7H6BrNO/c1-5(10)6-3-2-4-7(8)9-6/h2-4H,1H3
InChIKey RUJTWTUYVOEEFW-UHFFFAOYSA-N
SMILES C(=O)(C1=NC(Br)=CC=C1)C
CAS DataBase Reference 49669-13-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
NFPA 704
1
2 0

2-Acetyl-6-bromopyridine price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 597872 2-Acetyl-6-bromopyridine 97% 49669-13-8 1g $20.8 2025-07-31 Buy
Sigma-Aldrich 597872 2-Acetyl-6-bromopyridine 97% 49669-13-8 5g $197 2025-07-31 Buy
TCI Chemical A2404 2-Acetyl-6-bromopyridine >98.0%(GC) 49669-13-8 1g $41 2025-07-31 Buy
TCI Chemical A2404 2-Acetyl-6-bromopyridine >98.0%(GC) 49669-13-8 5g $123 2025-07-31 Buy
TRC A168505 2-Acetyl-6-bromopyridine 49669-13-8 10g $100 2021-12-16 Buy
Product number Packaging Price Buy
597872 1g $20.8 Buy
597872 5g $197 Buy
A2404 1g $41 Buy
A2404 5g $123 Buy
A168505 10g $100 Buy

2-Acetyl-6-bromopyridine Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

2-Acetyl-6-bromopyridine, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as OLED intermediate.

Synthesis

2,6-Dibromopyridine

626-05-1

N,N-Dimethylacetamide

127-19-5

2-Acetyl-6-bromopyridine

49669-13-8

General procedure for the synthesis of 2-acetyl-6-bromopyridine from 2,6-dibromopyridine and N,N-dimethylacetamide: 2,6-dibromopyridine (10.0 g, 42.2 mmol) was placed in a dry reaction flask. To ensure an inert atmosphere, the reaction flask was evacuated and replaced with nitrogen and repeated three times. 150 mL of anhydrous diethyl ether was added to the reaction flask and after cooling to -78 °C, n-butyllithium solution (17.7 mL, 44.3 mmol, 2.5 M in n-hexane) was slowly added dropwise and the color of the mixture was observed to change from clear to yellowish brown. Maintained at -78 °C and stirred continuously for 30 min. Subsequently, N,N-dimethylacetamide (4.7 mL, 50.7 mmol) was added slowly and the reaction was maintained at -78 °C for 3 hours. Upon completion of the reaction, the temperature was slowly increased to 20 °C, at which point the color of the mixture changed to a turbid gray. The reaction was quenched by the slow addition of deionized water. The solvent was removed by rotary evaporation and the residue was washed several times with ethyl acetate and saturated sodium chloride solution, the organic layers were combined and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:20) and then recrystallized in a mixture of dichloromethane and n-hexane solvent (dichloromethane/hexane=1:20) to give a white crystalline product (6.80 g, 81% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.97 (dd, J=7.0,1.6Hz, 1H), 7.68 (t, J=7.8Hz, 1H), 7.64 (dd, J=8.0,1.2Hz, 1H), 2.69 (s, 3H), and was confirmed as the target compound 2-acetyl-6-bromopyridine.

References

[1] Organometallics, 2016, vol. 35, # 2, p. 198 - 206
[2] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 1, p. 116 - 118
[3] Patent: US9219237, 2015, B1. Location in patent: Page/Page column 7
[4] Journal of Organic Chemistry, 2006, vol. 71, # 1, p. 167 - 175
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770

2-Acetyl-6-bromopyridine Preparation Products And Raw materials

Global( 248)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29731 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 933 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
Jinan Liheng Biotechnology Co., Ltd. 		15865262812 info@lihengpharm.com CHINA 938 58

View Lastest Price from 2-Acetyl-6-bromopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Acetyl-6-bromopyridine pictures 2021-08-21 2-Acetyl-6-bromopyridine
49669-13-8
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Acetyl-6-bromopyridine pictures 2021-07-02 2-Acetyl-6-bromopyridine
49669-13-8
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2-Acetyl-6-bromopyridine pictures 2020-05-13 2-Acetyl-6-bromopyridine
49669-13-8
 US $0.00-0.00 / Kg 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd

2-Acetyl-6-bromopyridine Spectrum

1-(6-Bromopyridine 2-Bromo-6-Acetylpyridine 1-(6-Bromopyridin-2-yl)ethan-1-one, 2-Bromo-6-ethanoylpyridine 2- acetyl-6-pyridyl broMide 6-Bromopyridin-2-yl methyl ketone 2-Acetyl-6-bromopyridine 97% 2-ACETYL-6-BROMOPYRIDINE 97 2-Acetyl-6-bromopyridine 1-(6-bromo-2-pyridyl)ethanone 1-(6-bromo-2-pyridinyl)ethanone 2-Acetyl-6-bromopyridine> Ethanone, 1-(6-bromo-2-pyridinyl)- 2-Acetyl-6-bromopyridine ISO 9001：2015 REACH 1-(6-Bromopyridin-2-yl)ethan-1-one 1-(6-Brompyridin-2-yl)ethanon 49669-13-8 Heterocycle-Pyridine series C7 and C8Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines