BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)-
- CAS No.
- 670256-21-0
- Chemical Name:
- BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)-
- Synonyms
- 4-Bromo-alpha-hydroxy-o-toluic acid;4-BroMo-2-(hydroxyMethyl)benzoic acid;BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)-
- CBNumber:
- CB52467705
- Molecular Formula:
- C8H7BrO3
- Molecular Weight:
- 231.04
- MDL Number:
- MFCD11977384
- MOL File:
- 670256-21-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918199890 |
BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)- price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR957980 | 4-Bromo-2-(hydroxymethyl)benzoicacid 95+% | 670256-21-0 | 100mg | $102 | 2021-12-16 | Buy |
| Apolloscientific | OR957980 | 4-Bromo-2-(hydroxymethyl)benzoicacid 95+% | 670256-21-0 | 250mg | $161 | 2021-12-16 | Buy |
| AK Scientific | 9284DA | 4-Bromo-2-(hydroxymethyl)benzoicacid | 670256-21-0 | 250mg | $240 | 2021-12-16 | Buy |
| Chemenu | CM123559 | 4-bromo-2-(hydroxymethyl)benzoicacid 95% | 670256-21-0 | 1g | $337 | 2021-12-16 | Buy |
| Crysdot | CD12044537 | 4-Bromo-2-(hydroxymethyl)benzoicacid 95+% | 670256-21-0 | 1g | $356 | 2021-12-16 | Buy |
BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)- Chemical Properties,Uses,Production
Synthesis
64169-34-2
670256-21-0
The general procedure for the synthesis of 4-bromo-2-hydroxymethylbenzoic acid using 5-bromophthalide as starting material was as follows: 5-bromophthaloyl (9 g, 0.042 mol) was dissolved in methanol (150 ml), 2N aqueous sodium hydroxide (100 ml) was added, and the reaction was carried out at reflux overnight. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrate was diluted with water and acidified with dilute hydrochloric acid to appropriate pH. The precipitated solid precipitate was collected by filtration and the residue was washed sequentially with cold water and cold ethyl acetate and dried to give 4-bromo-2-hydroxymethylbenzoic acid (9.7 g, 100% yield) as a white solid.
References
[1] Patent: US2008/15237, 2008, A1. Location in patent: Page/Page column 33
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 16, p. 7144 - 7167
[3] Patent: WO2015/89327, 2015, A1. Location in patent: Paragraph 0375
[4] Bulletin de la Societe Chimique de France, 1954, p. 769,772
[5] Journal of the Chemical Society, 1931, p. 867,869
BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
BENZOIC ACID, 4-BROMO-2-(HYDROXYMETHYL)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
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| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
