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ChemicalBook >> CAS DataBase List >>2,2'-Dithiodipyridine

2,2'-Dithiodipyridine

CAS No.
2127-03-9
Chemical Name:
2,2'-Dithiodipyridine
Synonyms
1,2-Di(pyridin-2-yl)disulfane;Aldrithiol;2-Aldrithiol;2-PDS;Dithiodipyridine;ALDRITHIOL-2;Dipyridyldisulfide;2-Pyridyl disulfide;1,2-Bis(2-pyridinyl) Disulfide;2PDS
CBNumber:
CB5200205
Molecular Formula:
C10H8N2S2
Molecular Weight:
220.31
MDL Number:
MFCD00006287
MOL File:
2127-03-9.mol
MSDS File:
SDS
Last updated:2025-02-12 16:52:28

2,2'-Dithiodipyridine Properties

Melting point 56-58 °C(lit.)
Boiling point 356.1±17.0 °C(Predicted)
Density 1.3078 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 210 °C
storage temp. 2-8°C
solubility methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
pka 1.52±0.19(Predicted)
form powder
color Clear colorless to yellow to tan
Water Solubility 5 g/L (20 ºC)
BRN 154629
InChIKey HAXFWIACAGNFHA-UHFFFAOYSA-N
LogP 2.530 (est)
CAS DataBase Reference 2127-03-9(CAS DataBase Reference)
FDA UNII L6X912UPBU
NIST Chemistry Reference Pyridine, 2,2'-dithiobis-(2127-03-9)
EPA Substance Registry System Pyridine, 2,2'-dithiobis- (2127-03-9)
UNSPSC Code 12352113
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-37-20/22
Safety Statements  36/37/39-37/39-25-22-36-26
RIDADR  UN 3335
WGK Germany  3
F  10-23
Autoignition Temperature 340 °C
Hazard Note  Irritant
TSCA  Yes
HS Code  29333990
NFPA 704
0
2 0

2,2'-Dithiodipyridine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 143049 Aldrithiol?-2 98% 2127-03-9 1g $67.2 2024-03-01 Buy
Sigma-Aldrich 8.41109 2,2′-Dipyridyl disulfide for synthesis 2127-03-9 5G $129 2024-03-01 Buy
Sigma-Aldrich 143049 Aldrithiol?-2 98% 2127-03-9 5g $128 2024-03-01 Buy
TCI Chemical D1114 2,2'-Dipyridyl Disulfide [for Peptide Synthesis] >98.0%(GC)(T) 2127-03-9 5g $54 2024-03-01 Buy
TCI Chemical D1114 2,2'-Dipyridyl Disulfide [for Peptide Synthesis] >98.0%(GC)(T) 2127-03-9 25g $162 2024-03-01 Buy
Product number Packaging Price Buy
143049 1g $67.2 Buy
8.41109 5G $129 Buy
143049 5g $128 Buy
D1114 5g $54 Buy
D1114 25g $162 Buy

2,2'-Dithiodipyridine Chemical Properties,Uses,Production

Chemical Properties

white to yellowish crystalline powder

Uses

2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.

Uses

2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.

Uses

2,2'-Dithiodipyridine was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.

Definition

ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines.

General Description

2,2'-Dithiodipyridine is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.

Biochem/physiol Actions

2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.

Purification Methods

Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare

2637-34-5
2127-03-9
Synthesis of 2,2'-Dithiodipyridine from 2-Pyridinethione
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View Lastest Price from 2,2'-Dithiodipyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vonoprazan Impurity 103 pictures 2025-04-18 Vonoprazan Impurity 103
2127-03-9
 US $0.00-0.00 / mg 10mg 95%+ 1000000 Moxin Chemicals
2,2'-Dithiodipyridine pictures 2025-04-15 2,2'-Dithiodipyridine
2127-03-9
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
2,2'-Dithiodipyridine pictures 2025-03-26 2,2'-Dithiodipyridine
2127-03-9
 US $0.00 / GK 1GK 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.
Bis(2-pyridyl) disulfide Di-2-Pyridyl disulfide Nsc 677438 Pyridine, 2,2'-dithiodi- ALDRITHIOL(TM)-2 2,2'-DIPYRIDYL DISULPHIDE 2-(PYRIDIN-2-YLDITHIO)PYRIDINE 2-PYRIDINYL DISULFIDE 2,2'-Dipyridyl Disulfide [for Peptide Synthesis] Pyridine, 2,2-dithiobis- 2,2''-DIPYRIDYL DISULFIDE 98+% NSC 94055 2,2'-Disulphanediyldipyridine, 2,2'-Dithiodipyridine Di(pyridin-2-yl) disulphide Aldrithiol(TM)-2 98% 1,2-Di(pyridin-2-yl)disulfide 2-(2-Pyridinyldisulfanyl)pyridine 2,2'-Dipyridinyl disulfide 2,2'-Dithiobis(pyridine) 2,2'-Dithiopyridine 2-Dipyridyl disulfide 2PDS Aldrithol-2 2,2'-Dithiodipyridine, >=99% Bis(pyridin-2-yl) disulfide 2,2μ-Dipyridyl disulfide, 2,2μ-Dithiodipyridine Aldritiol Di(2-pyridyl) persulfide 2,2'-Dithiodipyridine,98% 2,2'-Dithiodipyridin Bis(pyridin-2-yl) disulphide 2,2'- Dipyridil disulfide 2-(pyridin-2-yldisulfanyl)pyridine 2,2'-Bipyridyldisulfide Bis(2-pyridinyl) disulfide 2,2'-Dipyridyl disulfide, 98%, for synthesis 2,2'-DipyridylDisulfide[forPeptideSynthesis]> 2,2'-DIPYRIDYL DISULFIDE FOR SYNTHESIS 2,2'-Dithiodipyridine ISO 9001：2015 REACH 2-(2-Pyridyldisulfanyl)pyridine 9-[(3aS,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3H-purin-6-one Di(pyridin-2-yl) disulfide 1,2-Di(pyridin-2-yl ALDRITHIOL-2 2-PDS Dipyridyldisulfide 1,2-Di(pyridin-2-yl)disulfane 2-Pyridyl disulfide Aldrithiol Dithiodipyridine 1,2-Bis(2-pyridinyl) Disulfide 2-Aldrithiol 2,2'-Dithiodipyridine 2,2'-Dipyridyl disulfide 2,2'-Dipyridyl disulfide|||OPSS|||Aldrithiol 2|||Orthopyridyl disulfide 2,2''-Dithiodipyridine 2,2'-Dithiodipyridin Aldrithiol?-2