(6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol
- CAS No.
- 1469777-40-9
- Chemical Name:
- (6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol
- Synonyms
- Lumateperone Impurity 46
- CBNumber:
- CB513378010
- Molecular Formula:
- C23H28FN3O
- Molecular Weight:
- 381.49
- MDL Number:
- MOL File:
- 1469777-40-9.mol
(6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol Properties
Boiling point | 551.7±50.0 °C(Predicted) |
---|---|
Density | 1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
pka | 14.28±0.20(Predicted) |
FDA UNII | KDT972M5ZY |
(6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol Chemical Properties,Uses,Production
Uses
Lumateperone metabolite 1 (Formula T) is a metabolite of Lumateperone (HY-17637)[1]. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator[2][3]
References
[1] Sharon Mates, et al. Organic compounds. WO2015154025A1.
[2] Jinyuan Zhang, et al. Identification of Trovafloxacin, Ozanimod, and Ozenoxacin as Potent c-Myc G-quadruplex Stabilizers to Suppress c-Myc Transcription and Myeloma Growth. Mol Inform. 2022 Mar 30:e2200011. DOI:10.1002/minf.202200011
[3] J Titulaer, et al. Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D1 receptor dependent mechanism. Eur Neuropsychopharmacol. 2022 Jul 22;62:22-35. DOI:10.1016/j.euroneuro.2022.06.009
(6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol Preparation Products And Raw materials
Raw materials
Preparation Products
(6bR,10aS)-α-(4-Fluorophenyl)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-butanol Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TLC Pharmaceutical Standards Ltd. | 18012923235; 18012923235 | chinasales04@tlcstandards.com.cn | China | 7824 | 58 |
Hubei Rhema Reference Materials Technology Co., Ltd. | 0712-8899838 15787879035 | ydw9035@rmastandards.com | China | 9486 | 58 |
Supplier | Advantage |
---|---|
TLC Pharmaceutical Standards Ltd. | 58 |
Hubei Rhema Reference Materials Technology Co., Ltd. | 58 |