Nitecapone
- CAS No.
- 116313-94-1
- Chemical Name:
- Nitecapone
- Synonyms
- OR 462;Nitecapone;Nitecapone, 10 mM in DMSO;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
- CBNumber:
- CB51176592
- Molecular Formula:
- C12H11NO6
- Molecular Weight:
- 265.22
- MDL Number:
- MFCD00866318
- MOL File:
- 116313-94-1.mol
- MSDS File:
- SDS
| Melting point | 171-173°C |
|---|---|
| Boiling point | 495.3±45.0 °C(Predicted) |
| Density | 1.451±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 5.60±0.50(Predicted) |
| color | white to beige |
| FDA UNII | 98BS722498 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Nitecapone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0671 | Nitecapone ≥98% (HPLC) | 116313-94-1 | 5mg | $73.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0671 | Nitecapone ≥98% (HPLC) | 116313-94-1 | 25mg | $354 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 25mg | $288 | 2024-03-01 | Buy |
Nitecapone Chemical Properties,Uses,Production
Description
Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.
In vitro
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological activity
Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.
Chemical Properties
Yellow Solid
Uses
Inhibitor for the treatment of Parkinson disease
Uses
Inhibitor for the treatment of Parkinson's disease.
Definition
ChEBI: Nitecapone is a hydroxycinnamic acid.
Biological Activity
Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.
in vivo
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats[3].
| Animal Model: | Eighty-six male Wistar rats, weighing 140-350 g[3]. |
| Dosage: | 30 mg/kg (3.3 mL/kg). |
| Administration: | IP, once daily for 13 days. |
| Result: | Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h. Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia. Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats. |
Nitecapone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29805 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32351 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38759 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from Nitecapone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-22 | Nitecapone
116313-94-1
|
US $30.00-112.00 / mg | 99% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-02-02 | Nitecapone
116313-94-1
|
US $1.00 / g | 1g | 99% | 200g | Career Henan Chemical Co |
-
- Nitecapone
116313-94-1
- US $30.00-112.00 / mg
- 99%
- TargetMol Chemicals Inc.
-
- Nitecapone
116313-94-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co