Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI)
- CAS No.
- 314298-13-0
- Chemical Name:
- Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI)
- Synonyms
- 1-Fluoro-5-methoxy-2-methyl-4-nitrobenzene;5-Fluoro-4-methyl-2-nitroanisole;Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro-;Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI)
- CBNumber:
- CB51042460
- Molecular Formula:
- C8H8FNO3
- Molecular Weight:
- 185.15
- MDL Number:
- MFCD15527524
- MOL File:
- 314298-13-0.mol
- MSDS File:
- SDS
| Boiling point | 272.6±35.0 °C(Predicted) |
|---|---|
| Density | 1.270±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C8H8FNO3/c1-5-3-7(10(11)12)8(13-2)4-6(5)9/h3-4H,1-2H3 |
| InChIKey | JQNHPTUQNTUAJC-UHFFFAOYSA-N |
| SMILES | C1(F)=CC(OC)=C([N+]([O-])=O)C=C1C |
Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI) price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F597088 | 5-Fluoro-4-methyl-2-nitroanisole | 314298-13-0 | 250mg | $125 | 2021-12-16 | Buy |
| TRC | F597088 | 5-Fluoro-4-methyl-2-nitroanisole | 314298-13-0 | 25mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 132873 | 1-Fluoro-5-methoxy-2-methyl-4-nitrobenzene 97% | 314298-13-0 | 10g | $2700 | 2021-12-16 | Buy |
| Matrix Scientific | 132873 | 1-Fluoro-5-methoxy-2-methyl-4-nitrobenzene 97% | 314298-13-0 | 25g | $5040 | 2021-12-16 | Buy |
| Apolloscientific | PC902481 | 5-Fluoro-4-methyl-2-nitroanisole 98% | 314298-13-0 | 250mg | $150 | 2021-12-16 | Buy |
Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI) Chemical Properties,Uses,Production
Synthesis
106579-00-4
314298-13-0
The general procedure for the synthesis of 1-fluoro-5-methoxy-2-methyl-4-nitrobenzene from 5-methoxy-2-methyl-4-nitroaniline is as follows: pyridine (47.4 mL, 0.48 mol) and 70% hydrogen fluoride are placed in a plastic dispensing funnel under nitrogen protection and added dropwise to a plastic reaction flask at -78°C (dry ice/acetone bath) over a period of 20 minutes. Note: This process is an exothermic reaction. After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. Subsequently, 5-methoxy-2-methyl-4-nitroaniline (9.11 g, 0.05 mol) was added and stirring was continued for 10 minutes. Next, sodium nitrite (5.8 g, 0.08 mol) was added and stirring was continued for 10 minutes at -78 °C. The reaction mixture was gradually warmed up to room temperature and then heated to 60 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of an ice/water mixture (300 mL). The precipitate was collected by vacuum filtration, washed with water and dried under vacuum. The resulting solid product was recrystallized with methylcyclohexane to give the yellow crystalline title product 1-fluoro-5-methoxy-2-methyl-4-nitrobenzene (5.8 g, 63% yield). The structure of the product was confirmed by 1H NMR (300 MHz, chloroform-d): δ 7.82 (d, 1H), 6.75 (d, 1H), 3.93 (s, 3H), 2.25 (d, 3H).
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 21, p. 5661 - 5675
[2] Patent: US6420426, 2002, B1
[3] Patent: US2012/28924, 2012, A1. Location in patent: Page/Page column 25
Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI) Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9297 | 58 |
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2428 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Benzene, 1-fluoro-5-methoxy-2-methyl-4-nitro- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 1-Fluoro-5-methoxy-2-methyl-4-nitrobenzene
314298-13-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
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- 1-Fluoro-5-methoxy-2-methyl-4-nitrobenzene
314298-13-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
