4-Fluorobenzoic acid
- CAS No.
- 456-22-4
- Chemical Name:
- 4-Fluorobenzoic acid
- Synonyms
- PFBA;P-FLUOROBENZOIC ACID;potassium 2,2,3,3,3-pentafluoropropanoate;4-fluoro-benzoicaci;The acid;AKOS 92636;p-Fluorobenzoic;fluorobenzoicacid;Fluoro benzoic ac;4-Fluorbenzoesure
- CBNumber:
- CB4853637
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD00002530
- MOL File:
- 456-22-4.mol
- MSDS File:
- SDS
| Melting point | 182-184 °C (lit.) |
|---|---|
| Boiling point | 117 °C |
| Density | 1.479 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | alcohol: soluble |
| form | Crystalline Powder |
| pka | 4.15(at 25℃) |
| color | White to slightly yellow |
| Water Solubility | Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water. |
| Merck | 14,4171 |
| BRN | 1906922 |
| InChIKey | BBYDXOIZLAWGSL-UHFFFAOYSA-N |
| CAS DataBase Reference | 456-22-4(CAS DataBase Reference) |
| FDA UNII | V5ROO2HOU4 |
| NIST Chemistry Reference | Benzoic acid, 4-fluoro-(456-22-4) |
| EPA Substance Registry System | Benzoic acid, 4-fluoro- (456-22-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41-36/37/38 | |||||||||
| Safety Statements | 26-39-24/25-22-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | T | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163900 | |||||||||
| NFPA 704 |
|
4-Fluorobenzoic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | NIST2143 | p-Fluorobenzoic acid NIST?SRM? | 456-22-4 | 2g | $782 | 2025-07-31 | Buy |
| Sigma-Aldrich | 128384 | 4-Fluorobenzoic acid 98% | 456-22-4 | 5g | $18.3 | 2025-07-31 | Buy |
| Sigma-Aldrich | 128384 | 4-Fluorobenzoic acid 98% | 456-22-4 | 25g | $36.1 | 2025-07-31 | Buy |
| TCI Chemical | F0112 | 4-Fluorobenzoic Acid >98.0%(GC)(T) | 456-22-4 | 25g | $47 | 2025-07-31 | Buy |
| Sigma-Aldrich | 418846 | 4-Fluorobenzoic acid 99%, purified by sublimation | 456-22-4 | 1g | $42.1 | 2025-07-31 | Buy |
4-Fluorobenzoic acid Chemical Properties,Uses,Production
Description
4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the 18F labeling of antibodies. It has been used in high resolution charge density study.
Reference
AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356
Chemical Properties
white to light yellow crystal powder
Uses
4-Fluorobenzoic acid has been used in high resolution charge density study.
Definition
ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4.
Purification Methods
Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.]
4-Fluorobenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 925 | 55 |
| EAST STAR BIOTECH (SUZHOU) CO., LTD. | +8617706846989 | marketing@eaststarbio.com | China | 48 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8285 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 661 | 58 |
Related articles
- 4-Fluorobenzoic Acid: Applications in Radiosynthesis and Antimicrobial Research
- 4-Fluorobenzoic acid, a bacterial metabolite, is pivotal in radiopharmacy for automated synthesis of [18F]FBA and derivatives.
- Apr 22，2025
View Lastest Price from 4-Fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | 4-Fluorobenzoic acid
456-22-4
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-08-08 | 4-Fluorobenzoic acid
456-22-4
|
US $15.00 / KG | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2025-08-08 | 4-Fluorobenzoic acid
456-22-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- 4-Fluorobenzoic acid
456-22-4
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Fluorobenzoic acid
456-22-4
- US $15.00 / KG
- 99%
- Speranza Chemical Co., Ltd.
-
- 4-Fluorobenzoic acid
456-22-4
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
