Biological Activity

Peroxisome proliferator-activated receptor γ(PPAR-γ or PPARG) is a type II nuclear receptor encoded by the PPARG gene in humans. PPARs are ligand-activated transcription factors of the nuclear hormone receptor superfamily. PPARγ is expressed as two isoforms, PPARγ2 and PPARγ1. PPARγ2 is expressed at high levels in the adipose tissues, whereas PPARγ1 has a broader expression pattern. PPARγ2 in skeletal muscle can promote conversion of subcutaneous f at to brown f at formation leading to increased energy metabolisms and combating obesity. PPARγ mRNA is expressed in humans in spleen, bone marrow, liver, testis, skeletal muscle and brain, in addition to fat.