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ChemicalBook >> CAS DataBase List >>4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine

CAS No.
582313-57-3
Chemical Name:
4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine
Synonyms
SKL127;4-chloro-7-fluoro-7-deazapurine;6-Chloro-7-fluoro-7-deazapurine;4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine,4-chloro-5-fluoro-;4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 95+%;4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine ISO 9001：2015 REACH;6-Chloro-7-fluoro-7-deazapurine,4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
CBNumber:
CB41509263
Molecular Formula:
C6H3ClFN3
Molecular Weight:
171.56
MDL Number:
MFCD12924542
MOL File:
582313-57-3.mol
Last updated:2025-07-24 18:13:49

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine Properties

Density 1.642±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 9.72±0.50(Predicted)
Appearance Light yellow to brown Solid
InChI InChI=1S/C6H3ClFN3/c7-5-4-3(8)1-9-6(4)11-2-10-5/h1-2H,(H,9,10,11)
InChIKey OOBFPXOXHUBRDN-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2C(F)=CNC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P271-P280
HazardClass  IRRITANT
HS Code  2933599590

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C374270 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 582313-57-3 10mg $45 2021-12-16 Buy
Apolloscientific PC50028 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 95+% 582313-57-3 100mg $83 2021-12-16 Buy
SynQuest Laboratories 3H31-7-Y3 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 582313-57-3 100mg $133 2021-12-16 Buy
American Custom Chemicals Corporation HCH0143758 4-CHLORO-5-FLUORO-7H-PYRROLO[2,3-D]-PYRIMIDINE 95.00% 582313-57-3 500MG $864.17 2021-12-16 Buy
American Custom Chemicals Corporation HCH0143758 4-CHLORO-5-FLUORO-7H-PYRROLO[2,3-D]-PYRIMIDINE 95.00% 582313-57-3 1G $962.35 2021-12-16 Buy
Product number Packaging Price Buy
C374270 10mg $45 Buy
PC50028 100mg $83 Buy
3H31-7-Y3 100mg $133 Buy
HCH0143758 500MG $864.17 Buy
HCH0143758 1G $962.35 Buy

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine Chemical Properties,Uses,Production

Synthesis

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

22276-95-5

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine

582313-57-3

General procedure for the synthesis of 4-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidines from 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidines: 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidines (0.6 g, 2.60 mmol) were dissolved in 30 mL of dry tetrahydrofuran (THF) and cooled to -78 °C. 4.10 mL of n-butyllithium (nBuLi, 1.6 M solution in hexane) was added dropwise over 10 min. The reaction mixture was stirred at -78 °C for 20 min, followed by dropwise addition of N-fluorobenzenesulfonimide (NFSI, 3.38 mmol, 1.065 g, dissolved in 6.5 mL of anhydrous THF) over 15 min. The reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of 2 mL of water, and then the mixture was evaporated to dryness. The crude product was partitioned between ethyl acetate (EtOAc, 40 mL) and saturated ammonium chloride solution (20 mL), and the aqueous layer was extracted with 20 mL EtOAc. The organic layers were combined, washed with 20 mL of water and subsequently dried over anhydrous magnesium sulfate (MgSO?). After filtration, the solvent was evaporated. The crude product was purified by silica gel column chromatography using 4% methanol/dichloromethane (MeOH/CH?Cl?) as eluent to afford 4-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (0.36 g, 71% yield).1H NMR (DMSO-d?) δ: 7.70 (s, 1H), 8.62 (s, 1H), 12.25 (s, 1H (NH).

References

[1] Patent: WO2004/11478, 2004, A2. Location in patent: Page 27
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 21, p. 5284 - 5297
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7742 - 7747
[4] Patent: WO2015/143712, 2015, A1. Location in patent: Page/Page column 34; 35
[5] Patent: US2016/244475, 2016, A1. Location in patent: Paragraph 0310; 0313

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine Preparation Products And Raw materials

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29731 60
Nanjing Baifuli Technology Co., Ltd. 		+86-15335185688 sales@unisyn.cn CHINA 332 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22279 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58

View Lastest Price from 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Chloro-7-fluoro-7-deazapurine pictures 2025-04-29 6-Chloro-7-fluoro-7-deazapurine
582313-57-3
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine pictures 2021-12-04 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine
582313-57-3
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine pictures 2020-01-03 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine
582313-57-3
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine Spectrum

582313-57-3(4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine)Related Search:

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine 6-Chloro-7-fluoro-7-deazapurine 7H-Pyrrolo[2,3-d]pyriMidine,4-chloro-5-fluoro- 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 95+% 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine ISO 9001：2015 REACH SKL127 6-Chloro-7-fluoro-7-deazapurine,4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine 4-chloro-7-fluoro-7-deazapurine 582313-57-3 Other