ChemicalBook >> CAS DataBase List >>BET-IN-14
BET-IN-14
- CAS No.
- 2243669-93-2
- Chemical Name:
- BET-IN-14
- Synonyms
- BET-IN-14;2(1H)-Quinoxalinone, 4-cyclopentyl-3,4-dihydro-1,3-dimethyl-6-[1-(4-methylphenyl)-3-[(4-methyl-1-piperazinyl)carbonyl]-1H-1,2,4-triazol-5-yl]-, (3R)-
- CBNumber:
- CB414249512
- Molecular Formula:
- C30H37N7O2
- Molecular Weight:
- 527.66
- MDL Number:
- MOL File:
- 2243669-93-2.mol
Last updated:2025-04-28 21:36:36
BET-IN-14 Chemical Properties,Uses,Production
Uses
BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM). BET-IN-14 has anti-cancer activity[1].
in vivo
BET-IN-14 (Compound 171) (50 and 100 mg/kg, p.o., qd) inhibits tumor growth in MV-4-11 xenograft[1].
| Animal Model: | Human MV-4-11 xenografts in Balb/c nude mice[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | p.o., qd |
| Result: | Inhibited tumor growth by 60.36%. |
References
[1] Damaneh MS, et al. A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction. Invest New Drugs. 2020 Jun;38(3):700-713. DOI:10.1007/s10637-019-00818-z
BET-IN-14 Preparation Products And Raw materials
Raw materials
Preparation Products
BET-IN-14 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19903 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20701 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
BET-IN-14
2(1H)-Quinoxalinone, 4-cyclopentyl-3,4-dihydro-1,3-dimethyl-6-[1-(4-methylphenyl)-3-[(4-methyl-1-piperazinyl)carbonyl]-1H-1,2,4-triazol-5-yl]-, (3R)-
2243669-93-2