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ChemicalBook >> CAS DataBase List >>1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]-

1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]-

CAS No.
2493426-43-8
Chemical Name:
1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]-
Synonyms
HIV-1 inhibitor-43;1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]-
CBNumber:
CB412576542
Molecular Formula:
C24H21ClN2O4S
Molecular Weight:
468.95
MDL Number:
MOL File:
2493426-43-8.mol
Last updated:2025-04-29 09:03:59

1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- Properties

Boiling point 781.3±60.0 °C(Predicted)
Density 1.403±0.06 g/cm3(Predicted)
pka 9.76±0.30(Predicted)

1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- Chemical Properties,Uses,Production

Uses

HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression[1].

IC 50

HIV-1 (Y188L): 21.3 nM (EC50); HIV-1 (K103N+Y181C): 6.2 nM (EC50); HIV-1 (K103N): <0.7 nM (EC50); HIV-1 (Y181C): <0.7 nM (EC50)

References

[1] Nalli M, et al. New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains. Eur J Med Chem. 2020 Dec 15;208:112696. DOI:10.1016/j.ejmech.2020.112696

1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19927 58
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com; 18616537568 hanfangpharma@126.com China 29964 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 24803 58

View Lastest Price from 1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HIV-1 inhibitor-43 pictures 2025-04-29 HIV-1 inhibitor-43
2493426-43-8
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- HIV-1 inhibitor-43 2493426-43-8