ChemicalBook >> CAS DataBase List >>L-Leucine, N-(2,5-dichlorobenzoyl)glycyl-
L-Leucine, N-(2,5-dichlorobenzoyl)glycyl-
- CAS No.
- 1824976-81-9
- Chemical Name:
- L-Leucine, N-(2,5-dichlorobenzoyl)glycyl-
- Synonyms
- L-Leucine, N-(2,5-dichlorobenzoyl)glycyl-;N-(2,5-Dichlorobenzoyl)glycyl-L-leucine;(2S)-2-{2-[(2,5-dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid;(2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag
- CBNumber:
- CB410704989
- Molecular Formula:
- C15H18Cl2N2O4
- Molecular Weight:
- 361.22
- MDL Number:
- MOL File:
- 1824976-81-9.mol
Last updated:2025-01-27 09:38:02
L-Leucine, N-(2,5-dichlorobenzoyl)glycyl- Chemical Properties,Uses,Production
Uses
CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) th at degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.
CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.
L-Leucine, N-(2,5-dichlorobenzoyl)glycyl- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Leucine, N-(2,5-dichlorobenzoyl)glycyl- Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1598 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Supplier | Advantage |
|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 58 |
| Merck KGaA | 58 |
L-Leucine, N-(2,5-dichlorobenzoyl)glycyl-
(2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag
(2S)-2-{2-[(2,5-dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid
N-(2,5-Dichlorobenzoyl)glycyl-L-leucine
1824976-81-9