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ChemicalBook >> CAS DataBase List >>Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)-

Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)-

CAS No.
590416-75-4
Chemical Name:
Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)-
Synonyms
AK-106;AK106-001616;Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)-
CBNumber:
CB35491152
Molecular Formula:
C26H25N3O3
Molecular Weight:
427.49
MDL Number:
MOL File:
590416-75-4.mol
Last updated:2025-04-30 13:36:08

Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- Properties

Boiling point 654.8±55.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
pka 4.74±0.10(Predicted)
FDA UNII I2CST2BV1Q

Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- Chemical Properties,Uses,Production

Uses

AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis[1].

References

[1] Shimizu, Hirotomo, et al. AK106-001616, a potent and selective inhibitor of cytosolic phospholipase A2: in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics 369.3 (2019): 511-522. DOI:10.1124/jpet.118.255034

Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19903 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20701 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12000 58

View Lastest Price from Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AK-106 pictures 2025-04-30 AK-106
590416-75-4
 US $3700.00-2780.00 / mg 10g TargetMol Chemicals Inc.
  • AK-106 pictures
  • AK-106
    590416-75-4
  • US $3700.00-2780.00 / mg
  • TargetMol Chemicals Inc.
Benzenepropanoic acid, 3-amino-4-[(2,3-dihydro-1H-inden-2-yl)oxy]-5-(1-methyl-1H-indazol-5-yl)- AK106-001616 AK-106 590416-75-4