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ChemicalBook >> CAS DataBase List >>6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride

CAS No.
1849590-02-8
Chemical Name:
6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride
Synonyms
EFT-508.HCL;Tomivosertib HCl;tomivosertib hydrochloride;6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride
CBNumber:
CB33150848
Molecular Formula:
C17H21ClN6O2
Molecular Weight:
376.85
MDL Number:
MOL File:
1849590-02-8.mol
Last updated:2025-07-16 20:18:59

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride Properties

FDA UNII BW3S40K2UM

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride Chemical Properties,Uses,Production

Uses

Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance[2].

References

[1] Kevin R. Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL). Blood 2015 126:1554.
[2] Xu Y, et al. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 Feb;25(2):301-311. DOI:10.1038/s41591-018-0321-2

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride Suppliers

Global( 9)Suppliers
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TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19936 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1048 64
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4645 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7992 62
Wuhan Weiyuan Biotechnology Co., Ltd. 15608644787 13872128609@163.com CHINA 96 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9790 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 986 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58

View Lastest Price from 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tomivosertib HCl pictures 2025-07-16 Tomivosertib HCl
1849590-02-8
 US $3100.00-2380.00 / mg 10g TargetMol Chemicals Inc.
6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione hydrochloride EFT-508.HCL Tomivosertib HCl tomivosertib hydrochloride 1849590-02-8