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ChemicalBook >> CAS DataBase List >>4-BROMO-2-FLUORO-5-METHYLPYRIDINE

4-BROMO-2-FLUORO-5-METHYLPYRIDINE

CAS No.
1227577-02-7
Chemical Name:
4-BROMO-2-FLUORO-5-METHYLPYRIDINE
Synonyms
4-BROMO-2-FLUORO-5-METHYLPYRIDINE;Pyridine, 4-bromo-2-fluoro-5-methyl-
CBNumber:
CB32658460
Molecular Formula:
C6H5BrFN
Molecular Weight:
190.01
MDL Number:
MOL File:
1227577-02-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Properties

Boiling point 221.0±35.0 °C(Predicted)
Density 1.592±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 1.05±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

4-BROMO-2-FLUORO-5-METHYLPYRIDINE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B872683 4-Bromo-2-fluoro-5-methylpyridine 1227577-02-7 250mg $60 2021-12-16 Buy
TRC B872683 4-Bromo-2-fluoro-5-methylpyridine 1227577-02-7 2.5g $325 2021-12-16 Buy
TRC B872683 4-Bromo-2-fluoro-5-methylpyridine 1227577-02-7 1g $170 2021-12-16 Buy
AK Scientific Z1862 4-Bromo-2-fluoro-5-methylpyridine 1227577-02-7 1g $667 2021-12-16 Buy
Activate Scientific AS146963 4-Bromo-2-fluoro-5-methylpyridine 95% 1227577-02-7 250mg $147 2021-12-16 Buy
Product number Packaging Price Buy
B872683 250mg $60 Buy
B872683 2.5g $325 Buy
B872683 1g $170 Buy
Z1862 1g $667 Buy
AS146963 250mg $147 Buy

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Chemical Properties,Uses,Production

Uses

4-Bromo-2-fluoro-5-methylpyridine has properties and potential for diabetes treatment.

Synthesis

3-Bromo-2-fluoro-5-methylpyridine

17282-01-8

4-BROMO-2-FLUORO-5-METHYLPYRIDINE

1227577-02-7

General procedure for the synthesis of 4-bromo-2-fluoro-5-methylpyridine from 2-fluoro-3-bromo-5-methylpyridine: To a solution of 2-fluoro-3-bromo-5-methylpyridine (300 mg, 1.596 mmol) in tetrahydrofuran (THF, 10 mL) was added lithium diisopropylammonium (LDA, 2M, 0.8 mL) at -78°C and the reaction mixture was stirred at - 78 °C for 2 hours with stirring. Upon completion of the reaction, the reaction was quenched with 10 mL of water and extracted with ethyl acetate (EtOAc, 10 mL x 3). The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography (normal phase, silica gel, petroleum ether: ethyl acetate = 0-100%, UV 254 and UV 280 detection) to afford 4-bromo-2-fluoro-5-methylpyridine (130 mg, 43% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δppm: 2.37 (s, 3H), 7.19 (d 1H), 8.05 (s, 1H).

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6691 - 6703
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00181

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Preparation Products And Raw materials

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Suppliers

Global( 51)Suppliers
Supplier Tel Email Country ProdList Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd
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Aceschem Inc.
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LEAPCHEM CO., LTD.
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Aladdin Scientific
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Cochemical Co. Ltd.
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Compound Net Biotechnology Inc.
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Amadis Chemical Company Limited
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Adamas Reagent, Ltd. 400-6009262 16621234537 chenyj@titansci.com China 14101 59
Wuhan ariel chemical Co., LTD. 18986259541 sales@3stc.com China 3862 58
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3990 55

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Spectrum

4-BROMO-2-FLUORO-5-METHYLPYRIDINE Pyridine, 4-bromo-2-fluoro-5-methyl- 1227577-02-7