4-BROMO-2-FLUORO-5-METHYLPYRIDINE
- CAS No.
- 1227577-02-7
- Chemical Name:
- 4-BROMO-2-FLUORO-5-METHYLPYRIDINE
- Synonyms
- 4-BROMO-2-FLUORO-5-METHYLPYRIDINE;Pyridine, 4-bromo-2-fluoro-5-methyl-
- CBNumber:
- CB32658460
- Molecular Formula:
- C6H5BrFN
- Molecular Weight:
- 190.01
- MDL Number:
- MOL File:
- 1227577-02-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-BROMO-2-FLUORO-5-METHYLPYRIDINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B872683 | 4-Bromo-2-fluoro-5-methylpyridine | 1227577-02-7 | 250mg | $60 | 2021-12-16 | Buy |
| TRC | B872683 | 4-Bromo-2-fluoro-5-methylpyridine | 1227577-02-7 | 2.5g | $325 | 2021-12-16 | Buy |
| TRC | B872683 | 4-Bromo-2-fluoro-5-methylpyridine | 1227577-02-7 | 1g | $170 | 2021-12-16 | Buy |
| AK Scientific | Z1862 | 4-Bromo-2-fluoro-5-methylpyridine | 1227577-02-7 | 1g | $667 | 2021-12-16 | Buy |
| Activate Scientific | AS146963 | 4-Bromo-2-fluoro-5-methylpyridine 95% | 1227577-02-7 | 250mg | $147 | 2021-12-16 | Buy |
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Chemical Properties,Uses,Production
Uses
4-Bromo-2-fluoro-5-methylpyridine has properties and potential for diabetes treatment.
Synthesis
17282-01-8
1227577-02-7
General procedure for the synthesis of 4-bromo-2-fluoro-5-methylpyridine from 2-fluoro-3-bromo-5-methylpyridine: To a solution of 2-fluoro-3-bromo-5-methylpyridine (300 mg, 1.596 mmol) in tetrahydrofuran (THF, 10 mL) was added lithium diisopropylammonium (LDA, 2M, 0.8 mL) at -78°C and the reaction mixture was stirred at - 78 °C for 2 hours with stirring. Upon completion of the reaction, the reaction was quenched with 10 mL of water and extracted with ethyl acetate (EtOAc, 10 mL x 3). The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography (normal phase, silica gel, petroleum ether: ethyl acetate = 0-100%, UV 254 and UV 280 detection) to afford 4-bromo-2-fluoro-5-methylpyridine (130 mg, 43% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δppm: 2.37 (s, 3H), 7.19 (d 1H), 8.05 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6691 - 6703
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00181
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Cochemical Co. Ltd. | +86-029-86115547 +86-17791676824 | sales@cochemical.com | China | 3952 | 58 |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | chenyj@titansci.com | China | 14101 | 59 |
| Wuhan ariel chemical Co., LTD. | 18986259541 | sales@3stc.com | China | 3862 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3990 | 55 |