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ChemicalBook >> CAS DataBase List >>TRIM24/BRPF1-IN-2

TRIM24/BRPF1-IN-2

CAS No.
3033288-68-2
Chemical Name:
TRIM24/BRPF1-IN-2
Synonyms
TRIM24/BRPF1-IN-2;Benzenesulfonamide, N-(1-acetyl-2,3-dihydro-1H-indol-5-yl)-5-cyclopropyl-2-methoxy-
CBNumber:
CB314294782
Molecular Formula:
C20H22N2O4S
Molecular Weight:
386.47
MDL Number:
MOL File:
3033288-68-2.mol
Last updated:2025-05-16 15:57:46

TRIM24/BRPF1-IN-2 Properties

Boiling point 651.3±65.0 °C(predicted)
Density 1.370±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 7.89±0.20(predicted)

TRIM24/BRPF1-IN-2 Chemical Properties,Uses,Production

Uses

TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research[1].

in vivo

TRIM24/BRPF1-IN-2 (compound 20l) (50 mg/kg, IP, once daily for 21 days) suppresses tumor growth (TGI = 53%) without exhibiting noticeable toxicity[1].

Animal Model:Mice (n = 5-7 per dose group, Four-week-old, male, non-obese diabetic server combined immune-deficiency (NOD SCID), 22Rv1 xenograft model)[1]
Dosage:50 mg/kg
Administration:IP, once daily for 21 days
Result:Inhibited the progression of the tumors significantly (53% tumor growth inhibition) without body weight loss.

IC 50

BRPF1: 1.16 μM (IC50)

References

[1] Xiang Q, et al. Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. Eur J Med Chem. 2022 Jun 5;236:114311. DOI:10.1016/j.ejmech.2022.114311

TRIM24/BRPF1-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

TRIM24/BRPF1-IN-2 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32282 58
Guangzhou Younan Technology Co., Ltd 020-82000279 18988968278 YN_research@163.com China 3000 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24891 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20701 58

View Lastest Price from TRIM24/BRPF1-IN-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TRIM24/BRPF1-IN-2 pictures 2025-05-16 TRIM24/BRPF1-IN-2
3033288-68-2
 US $970.00-335.00 / mg 99.13% 10g TargetMol Chemicals Inc.
TRIM24/BRPF1-IN-2 Benzenesulfonamide, N-(1-acetyl-2,3-dihydro-1H-indol-5-yl)-5-cyclopropyl-2-methoxy- 3033288-68-2