午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> CAS DataBase List >>Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-

CAS No.
2444364-04-7
Chemical Name:
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-
Synonyms
EGFR/HER2/TS-IN-2;Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-
CBNumber:
CB312645230
Molecular Formula:
C26H21N7OS2
Molecular Weight:
511.62
MDL Number:
MOL File:
2444364-04-7.mol
Last updated:2025-04-18 09:51:59

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Properties

Density 1.41±0.1 g/cm3(Predicted)
pka 8.10±0.70(Predicted)

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Chemical Properties,Uses,Production

Uses

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1].

IC 50

HER2: 0.125 ± 0. μM (IC50); EGFR: 0.173 ± 0. μM (IC50)

References

[1] Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. DOI:10.1016/j.bioorg.2020.103976

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19930 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 25122 58

View Lastest Price from Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EGFR/HER2/TS-IN-2 pictures 2025-05-02 EGFR/HER2/TS-IN-2
2444364-04-7
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- EGFR/HER2/TS-IN-2 2444364-04-7 C26H21N7OS2