H-Met-Gly-Met-Met-OH
- CAS No.
- 299898-33-2
- Chemical Name:
- H-Met-Gly-Met-Met-OH
- Synonyms
- CBNumber:
- CB312574556
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
H-Met-Gly-Met-Met-OH Chemical Properties,Uses,Production
Uses
Acetyl Gastric Inhibitory Peptide (human) is a fatty acid derivatized analog of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Acetyl Gastric Inhibitory Peptide (human) can be used for research of diabetes, insulin resistance and obesity[1][2][3].
in vivo
Acetyl Gastric Inhibitory Peptide (human) (25 nmol/kg; i.p.; single dose) shows resistance to plasma dipeptidylpeptidase IV degradation, resulting in enhanced biological activity and improved antidiabetic potential in vivo[1].
| Animal Model: | Obese hyperglycaemic (ob/ob) mice[1] |
| Dosage: | 25 nmol/kg |
| Administration: | Intraperitoneal injection; single dose |
| Result: | Lowered individual glucose values at 60 min together with the areas under the curve for glucose compared to native GIP. |
References
[1] O'Harte FP, et al. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia. 2002 Sep;45(9):1281-91. DOI:10.1007/s00125-002-0894-6
[2] Gault Victor A, et al. GIP peptide analogues for treatment of diabetes, insulin resistance and obesity: World Intellectual Property Organization, WO2005082928[P]. 2005-12-01.
[3] O'Harte, et al. Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function: World Intellectual Property Organization, WO2007028632[P].2007-03-15.
H-Met-Gly-Met-Met-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-Met-Gly-Met-Met-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5220 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4800 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7222 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13173652190 | pomy@tanzhenbio.com | China | 2067 | 58 |
| Hangzhou Go Top Peptide Biotech | 15397062932 | sales1@gotopbio.com | China | 2905 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-88211921 19105816207 | 1092698600@qq.com | China | 5146 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6791 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
| Combio (Suzhou) Ltd. | 0512-0512-51886999 17706251929 | office@combiosz.com | China | 3001 | 58 |
| Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211951 13735575465 | sales1@gotopbio.com | China | 4880 | 58 |