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ChemicalBook >> CAS DataBase List >>3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)-

3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)-

CAS No.
1335145-56-6
Chemical Name:
3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)-
Synonyms
A424274;A-424274;A 424274;3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)-
CBNumber:
CB310618702
Molecular Formula:
C14H15N3
Molecular Weight:
225.29
MDL Number:
MOL File:
1335145-56-6.mol
Last updated:2025-04-18 09:51:57

3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- Properties

Boiling point 418.1±20.0 °C(Predicted)
Density 1.225±0.06 g/cm3(Predicted)
pka 10.53±0.20(Predicted)

3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- Chemical Properties,Uses,Production

Description

A-424274 is an α4β2 neuronal nicotinic receptor positive allosteric modulator.

Uses

A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.

References

[1] α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain DOI:10.1016/j.bcp.2011.06.044

3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- Preparation Products And Raw materials

Raw materials

Preparation Products

3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32346 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19925 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 24571 58

View Lastest Price from 3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
A-424274 pictures 2024-10-24 A-424274
1335145-56-6
 US $2120.00-2780.00 / mg 10g TargetMol Chemicals Inc.
  • A-424274 pictures
  • A-424274
    1335145-56-6
  • US $2120.00-2780.00 / mg
  • TargetMol Chemicals Inc.
3,6-Diazabicyclo[3.2.0]heptane, 3-(3-quinolinyl)-, (1S,5S)- A 424274 A424274 A-424274 1335145-56-6