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ChemicalBook >> CAS DataBase List >>AST2818 mesylate

AST2818 mesylate

CAS No.
2130958-55-1
Chemical Name:
AST2818 mesylate
Synonyms
Alflutinib mesylate;Furmonertinib;AST2818 mesylate;ASK120067 mesylate;Furmonertinib mesylate;Firmonertinib mesylate;Alflutinib methanesulfonate;Alflutinib mesylate (AST2818);Alflutinib (AST2818 mesylate);Firmonertinib (AST2818) mesylate
CBNumber:
CB24797023
Molecular Formula:
C29H35F3N8O5S
Molecular Weight:
664.71
MDL Number:
MFCD31746903
MOL File:
2130958-55-1.mol
Last updated:2025-07-18 08:49:11

AST2818 mesylate Properties

storage temp. Store at -20°C,unstable in solution, ready to use.
solubility Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble
form A crystalline solid
color Light yellow to yellow
InChIKey WDPGHXINXNBHAS-UHFFFAOYSA-N
SMILES S(O)(=O)(=O)C.CN1C2=CC=CC=C2C(C2C=CN=C(NC3C=C(NC(=O)C=C)C(N(C)CCN(C)C)=NC=3OCC(F)(F)F)N=2)=C1
FDA UNII Q09ZKD19V0
NCI Drug Dictionary alflutinib mesylate

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

AST2818 mesylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0067492 AST2818mesylate 99.99% 2130958-55-1 5mg $200 2021-12-16 Buy
ChemScene CS-0067492 AST2818mesylate 99.99% 2130958-55-1 10mg $300 2021-12-16 Buy
ChemScene CS-0067492 AST2818mesylate 99.99% 2130958-55-1 50mg $850 2021-12-16 Buy
ChemScene CS-0067492 AST2818mesylate 99.99% 2130958-55-1 100mg $1250 2021-12-16 Buy
Biorbyt Ltd orb573198 Alflutinib mesylate (AST2818) 2130958-55-1 100mg $1283.5 2021-12-16 Buy
Product number Packaging Price Buy
CS-0067492 5mg $200 Buy
CS-0067492 10mg $300 Buy
CS-0067492 50mg $850 Buy
CS-0067492 100mg $1250 Buy
orb573198 100mg $1283.5 Buy

AST2818 mesylate Chemical Properties,Uses,Production

Description

Furmonertinib (formerly known as alflutinib) is another me-too third-generation EGFR TKI that has a pyridyl ring replacing the phenyl ring of osimertinib and a trifluoroethyl group replacing the methyl group (Fig. 4). This TKI, which was discovered and developed by Shanghai Allist Pharma, was approved in November 2019 by the NMPA of China for the second-line treatment of NSCLC with EGFR sensitive mutation and EGFR T790M drug-resistant mutation, and more recently as a first-line treatment for classical EGFR mutant NSCLC. In June 2022, furmonertinib was granted the Fast Track designation by the FDA in patients with advanced or metastatic NSCLC with activating EGFR or HER2 mutations, including exon 20 insertion mutations.

Uses

Firmonertinib (Alflutinib; Furmonertinib) mesylate is is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation[1].

IC 50

EGFR

References

[1] Y. Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.
[2] Alexander I. Spira, et al. FURVENT: Phase 3 trial of furmonertinib vs chemotherapy as first-line treatment for advanced NSCLC with EGFR exon 20 insertion mutations (FURMO-004). Journal of Clinical Oncology. Volume 42, Number 16_suppl

AST2818 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

AST2818 mesylate Suppliers

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32350 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9297 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38755 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 6035 58

View Lastest Price from AST2818 mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Alflutinib mesylate pictures 2025-07-17 Alflutinib mesylate
2130958-55-1
 US $71.00-247.00 / mg 99.81% 10g TargetMol Chemicals Inc.
AST2818 mesylate pictures 2025-04-04 AST2818 mesylate
2130958-55-1
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • AST2818 mesylate pictures
  • AST2818 mesylate
    2130958-55-1
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-2-propenamide compd. with methanesulfonate (1:1) AST2818 mesylate Alflutinib mesylate (AST2818) Alflutinib methanesulfonate Alflutinib (AST2818 mesylate) Alflutinib mesylate Alflutinib mesylate (Furmonertinib) Furmonertinib mesylate cancer,Epidermal growth factor receptor,AST2818,esistant mutation,Alflutinib,Alflutinib mesylate,AST-2818,Furmonertinib,HER1,AST 2818,NSCLC,ErbB-1,Inhibitor,EGFR,T790M,inhibit N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate ASK120067 mesylate Furmonertinib Firmonertinib (AST2818) mesylate Alflutinib (Furmonertinib) mesylate Firmonertinib mesylate 2130958-55-1