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ChemicalBook >> CAS DataBase List >>Phenibut

Phenibut

CAS No.
1078-21-3
Chemical Name:
Phenibut
Synonyms
Phenibut HCL;4-AMINO-3-PHENYLBUTYRIC ACID HCL;FENIBUT;Phenybut;Phenibut Powder;fenigam;phenylgam;Aminophenylbutyric acid;4-AMINO-3-PHENYLBUTIRIC ACID;-Amino-3-phenylbutyric acid hydrochloride
CBNumber:
CB2316925
Molecular Formula:
C10H13NO2
Molecular Weight:
179.22
MDL Number:
MFCD00456233
MOL File:
1078-21-3.mol
Last updated:2025-07-16 16:08:20

Phenibut Properties

Melting point 252.5°C (rough estimate)
Boiling point 311.75°C (rough estimate)
Density 1.1248 (rough estimate)
refractive index 1.5710 (estimate)
solubility Free base: 35 mg/mL in DMSO (195.29 mM) at 25 °C (SellekChem, 2019).Hydrochloride salt (Cayman, 2016): 25 mg/ml in DMF; 20 mg/ml in DMSO; 14 mg/ml in ethanol; 10 mg/mL in PBS (pH 7.2).
pka 4.10±0.10(Predicted)
form solid
color White
InChI InChI=1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)
InChIKey DAFOCGYVTAOKAJ-UHFFFAOYSA-N
SMILES C(O)(=O)CC(C1=CC=CC=C1)CN
CAS DataBase Reference 1078-21-3(CAS DataBase Reference)
FDA UNII T2M58D6LA8
EPA Substance Registry System Benzenepropanoic acid, .beta.-(aminomethyl)- (1078-21-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2922498590
Toxicity TDLo orl-hmn: 5 mg/kg:CNS BEXBAN 57,52,64

Phenibut price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P2974 Phenibut 1078-21-3 5G $82 2025-07-31 Buy
TCI Chemical P2974 Phenibut 1078-21-3 25G $246 2025-07-31 Buy
TRC A630595 4-Amino-3-phenylbutanoicAcid 1078-21-3 1g $40 2021-12-16 Buy
TRC A630595 4-Amino-3-phenylbutanoicAcid 1078-21-3 10g $65 2021-12-16 Buy
Matrix Scientific 008053 4-Amino-3-phenyl-butyric acid hydrochloride 1078-21-3 1g $72 2021-12-16 Buy
Product number Packaging Price Buy
P2974 5G $82 Buy
P2974 25G $246 Buy
A630595 1g $40 Buy
A630595 10g $65 Buy
008053 1g $72 Buy

Phenibut Chemical Properties,Uses,Production

Description

Phenibut, also known as fenibut, phenigamma, and beta-phenyl-gamma-aminobutyric acid, is a derivative of the neurotransmitter GABA. It was developed in Russia,and there it has been used clinically since the 1960s to treat anxiety and related conditions,including insomnia(Lapin,2001). Phenibut has anxiolytic properties and is commonlycompared to benzodiazepines and baclofen.Structurally,phenibut issimilar to GABA, with the addition of the phenyl ring. This allows thecompound to more easily cross the blood-brain barrier, but also changesits activity profile (Shulgina,1986). Scientific studies demonstrate that phenibut can be safely used to treat anxiety, depression,epilepsy, speech disorders, and insomnia.

Uses

4-amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.

Preparation

Phenibut was synthesized by Perekalin and his associates at the Department of Organic Chemistry of the Herzen Pedagogic Institute in St. Petersburg, the Russian Federation. In initial publications phenibut was known as phenigamma (Lapin, 2001, V. V. Perekalin, 1954).
Fenibut synthesis: from benzoyl chloride and ethyl acetoacetate as raw materials, through condensation and hydrolysis of ethyl benzoyl acetate, and then condensation of benzaldehyde and nitromethane to generate trans-nitrostyrene, and then the two are combined. Micheal addition, the adduct is then catalytically hydrogenated with Raney nickel, and finally hydrolyzed in concentrated hydrochloric acid to produce phenibate.
Synthesis of Phenibut (16) and Baclofen (17)
Synthesis of Phenibut (16) and Baclofen (17).

Application

Phenibut is an anxiolytic and nootropic drug, discovered in the Soviet Union used to treat several psychiatric disorders. It can be used in the treatment of anxiety, depression, asthenia, post-traumatic stress disorder, stuttering, and vestibular disorders.

Definition

ChEBI: Phenibut is an organonitrogen compound and an organooxygen compound. It is functionally related to a gamma-amino acid.

Side effects

When taken by mouth: Phenibut is likely unsafe. Phenibut can cause many side effects, including reduced consciousness, dizziness, nausea, poor balance, and fatigue. Taking large doses can cause trouble breathing, unconsciousness, and death.
Phenibut can cause dependence. People who use phenibut for 3 days or more and then stop taking it might experience withdrawal symptoms. These symptoms can include decreased appetite, nausea, muscle aches, fast heart rate, anxiety, agitation, trouble sleeping, and seizures.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: somnolence, hallucinations, distorted perception. Used as a mood elevator and tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Drug interactions

Pregabalin (Lyrica) interacts with Phenibut: Phenibut acts on the brain in a similar way to pregabalin. Taking these two chemicals together might increase the risk for side effects.
Sedative medications (CNS depressants) interacts with Phenibut: Phenibut might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking phenibut with sedative medications might cause breathing problems and/or too much sleepiness.

Regulatory Status

USA - Phenibut is still an uncontrolled substance in the United States, and it is legal to sell and possess phenibut. It has not been approved for clinical use in the United States.
Europe - Unscheduled. It is not regulated by the European Medicines Agency. However, some nootropic substances such as piracetam are available only on prescription in some European Union countries and are freely available in others.
Russia - Phenibut is a licensed prescription medication used for a variety of conditions including anxiety, insomnia, post-traumatic stress disorders, depression, stuttering, tics, attention deficit disorders, and vestibular disorders. Russian cosmonauts were reported to have been supplied with the substance to help relieve tension, anxiety and fear (Buckley 2006).

1198-97-6
1078-21-3
Synthesis of Phenibut from 4-Phenyl-2-pyrrolidinone

Phenibut Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 402)Suppliers
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Shaanxi Xianhe Biotech Co., Ltd
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View Lastest Price from Phenibut manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-3-phenylbutanoic acid pictures 2025-08-05 4-Amino-3-phenylbutanoic acid
1078-21-3
US $10.00 / ASSAYS 1ASSAYS 99% 100kg RongNa Biotechnology Co.,Ltd
Phenibut pictures 2025-08-05 Phenibut
1078-21-3
US $1.00 / kg 0.10000000kg 99% 200KG Jinan Million Pharmaceutical Co., Ltd
Phenibut pictures 2025-08-05 Phenibut
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US $2.50 / kg 1kg 99.32 60 tons Jinan Million Pharmaceutical Co., Ltd
  • Phenibut pictures
  • Phenibut
    1078-21-3
  • US $1.00 / kg
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Phenibut pictures
  • Phenibut
    1078-21-3
  • US $2.50 / kg
  • 99.32
  • Jinan Million Pharmaceutical Co., Ltd
NA###4-Amino-3-phenylbutyric acid hydrochloride TIMTEC-BB SBB001567 fenigama pgaba phenigam phenigama phenylgamma AMINOBUTYRIC ACID, beta-PHENYL-gaMMa-(P) Phenygam 4-azanyl-3-phenyl-butanoic acid (4-hydroxy-4-keto-2-phenyl-butyl)ammonium chloride (4-hydroxy-4-oxo-2-phenylbutyl)ammonium chloride (4-hydroxy-4-oxo-2-phenyl-butyl)ammonium chloride (4-hydroxy-4-oxo-2-phenylbutyl)azanium chloride (4-hydroxy-4-oxo-2-phenyl-butyl)azanium chloride HYDROCINNAMIC ACID, beta-(AMINOMETHYL)-, HYDROCHLORIDE 4-amino-3-phenylbutanoicacid 4-amino-3-phenyl-butyricaci beta-(aminomethyl)-benzenepropanoicaci beta-(aminomethyl)benzenepropanoicacid beta-(aminomethyl)hydrocinnamicacid beta-phenyl-gamma-aminobutyrate beta-phenyl-gamma-aminobutyricacid 4-AMINO-3-PHENYL-BUTYRIC ACID 4-AMINO-3-PHENYL BUTYRIC ACID HYDROCHLORIDE 4-Amino-3-pheny-butyric acid 4-Amino-3-phenyl 4-AMINO-3-PHENY-BUTYRICACIDHYDROCHLORIDE PHENYLBUT (4-AMINO-3-PHENYLBUTYRIC ACID HCL) 3-PHENYL-4-AMINOBUTYRICACIDHCL 4-Amino-3-phenylbutyric acid hydrchloride B-(Aminomethyl)-benzenepropionic acid hydrochloride Phenibut (4-AMino-3-phenylbutyric acid HCl) Benzenepropanoic acid, b-(aMinoMethyl)- Benzenepropanoic acid, .beta.-(aminomethyl)- PHENIBUT PHENIBUTCAS NO.: 1078-21-3 Phenibut CAS NO.1078-21-3 Nootropics Powder Nutrition Supplement Phenibut for Fatigue Reduce CAS 1078-21-3 Phenibut 4-Amino-3-Phenylbutyric Acid 4-Amino-3-phenylbutanoic acid Hydrochloride, Phenibut PhGABA β-Phenyl-γ-aminobutyric acid butyric Acid HydrochL Benzenepropanoic acid, β-(aminomethyl)- Phenibut Company Standards Phenibut HCl Powder 4-Amino-3-phenylbutanoic acid USP/EP/BP Phenibut, 4-Amino-3-phenylbutanoic acid Fenibut Phenibut Hot Sale Phenibut Powder 99% Phenibut/Phenibut HCl CAS?1078-21-3 4-Amino-3-Phenylbutanoic Acid/Phenibut 4-AMINO-3-PHENYLBUTIRIC ACID -Amino-3-phenylbutyric acid hydrochloride FENIBUT Phenybut fenigam 4-AMINO-3-PHENYLBUTYRIC ACID HCL Phenibut HCL