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ChemicalBook >> CAS DataBase List >>M2698

M2698

CAS No.
1379545-95-5
Chemical Name:
M2698
Synonyms
M2698;M2698, 10 mM in DMSO;M2698 (MSC-2363318A);M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A;(S)-4-(2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethylamino)quinazoline-8-carboxamide;4-{[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino}quinazoline-8-carboxamide;8-Quinazolinecarboxamide, 4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]-;4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethylphenyl)ethylamino]quinazoline-8-carboxylic acid amide
CBNumber:
CB23152911
Molecular Formula:
C21H19ClF3N5O
Molecular Weight:
449.86
MDL Number:
MFCD31744446
MOL File:
1379545-95-5.mol
Last updated:2025-07-31 22:42:24

M2698 Properties

solubility DMSO: soluble
form A solid
color White to off-white
InChIKey HXAUJHZZPCBFPN-QGZVFWFLSA-N
SMILES N1=C2C(C=CC=C2C(N)=O)=C(N[C@@H](C2=CC=C(Cl)C(C(F)(F)F)=C2)CN2CCC2)N=C1
FDA UNII 0DXG50I4WD

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

M2698 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0019628 M2698 99.74% 1379545-95-5 5mg $650 2021-12-16 Buy
DC Chemicals DC10751 M2698(MSC-2363318A) >98% 1379545-95-5 100mg $750 2021-12-16 Buy
DC Chemicals DC10751 M2698(MSC-2363318A) >98% 1379545-95-5 250mg $1300 2021-12-16 Buy
Product number Packaging Price Buy
CS-0019628 5mg $650 Buy
DC10751 100mg $750 Buy
DC10751 250mg $1300 Buy

M2698 Chemical Properties,Uses,Production

Uses

M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1].

in vivo

M2698 (10-30 mg/kg/day; PO; 28 days) results in dose-dependent inhibition of tumor growth and results in tumor regression with the highest dose of 30 mg/kg[1].
? M2698 (20 mg/kg/day; PO; 4 days) has a tumor:plasma exposure ratio of 12:1 over 24 hours and leads to increased levels of pAkt in tumor tissue[1].
? The mean total concentration of M2698 after 16-hour infusion in rats is 1750 ng/g and 175 ng/mL in brain and plasma, respectively[1].
? M2698 (po; 1, 5, 10, or 20 mg/kg/day; for 7 days) inhibits the phosphorylation of S6 in a dose-proportional manner over time after a single administration or daily treatments over 7 days[1].

Animal Model:Female nude mice bearing MDA-MB-468 tumors[1]
Dosage:10, 20 and 30 mg/kg
Administration:PO; daily; for 28 days
Result:Resulted in dose-dependent inhibition of tumor growth and resulted in tumor regression with the highest dose of 30 mg/kg.
Animal Model:Female SCID Beige mice with MDA-MB-453 xenografted[1]
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:Daily; for 4 days
Result:Had a tumor:plasma exposure ratio of 12:1 over 24 hours.

IC 50

p70S6K: 1 nM (IC50); Akt1: 1 nM (IC50); Akt3: 1 nM (IC50)

References

[1] Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18. PMID:27186432

M2698 Preparation Products And Raw materials

Raw materials

Preparation Products

M2698 Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1521 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
SuZhou GoodChemTech Co., Ltd 18136139868; 18136139868 jinlun@goodchemtech.cn China 272 58
Zhengzhou Haode Pharmaceutical Technology Co.,Ltd 18037386321 3330511471@qq.com China 284 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55

View Lastest Price from M2698 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
M2698 pictures 2025-07-31 M2698
1379545-95-5
 US $43.00-173.00 / mg 99.36% 10g TargetMol Chemicals Inc.
M2698 pictures 2025-07-15 M2698
1379545-95-5
 US $43.00-173.00 / mg 99.36% 10g TargetMol Chemicals Inc.
M2698 pictures 2019-12-26 M2698
1379545-95-5
 US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • M2698 pictures
  • M2698
    1379545-95-5
  • US $43.00-173.00 / mg
  • 99.36%
  • TargetMol Chemicals Inc.
  • M2698 pictures
  • M2698
    1379545-95-5
  • US $43.00-173.00 / mg
  • 99.36%
  • TargetMol Chemicals Inc.
  • M2698 pictures
  • M2698
    1379545-95-5
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co
M2698 (S)-4-(2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethylamino)quinazoline-8-carboxamide M2698 (MSC-2363318A) M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A 4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethylphenyl)ethylamino]quinazoline-8-carboxylic acid amide 8-Quinazolinecarboxamide, 4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]- 4-{[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino}quinazoline-8-carboxamide M2698, 10 mM in DMSO 1379545-95-5