RO2959 Hydrochloride
- CAS No.
- 1219927-22-6
- Chemical Name:
- RO2959 Hydrochloride
- Synonyms
- SYN5226;RO2959 HCl;RO2959 Hydrochloride;RO2959 Hydrochloride, 10 mM in DMSO;IP3,SOCE,Ca2+ release-activated Ca2+ channels,RO2959 Hydrochloride,Interleukin Related,inhibit,IL-2,Stim1,RO-2959 Hydrochloride,CRAC Channel,anti-proliferation,RO 2959,Calcium release-activated channels,T-cell,RO-2959,Orai1,heart,RO2959,Inhibitor,failure
- CBNumber:
- CB23067576
- Molecular Formula:
- C21H20ClF2N5OS
- Molecular Weight:
- 463.93
- MDL Number:
- MOL File:
- 1219927-22-6.mol
RO2959 Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0063986 | RO2959hydrochloride | 1219927-22-6 | 5mg | $350 | 2021-12-16 | Buy |
| AK Scientific | SYN5226 | RO2959Hydrochloride | 1219927-22-6 | 100mg | $2635.25 | 2021-12-16 | Buy |
| DC Chemicals | DC33579 | RO2959Hydrochloride | 1219927-22-6 | 100mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC33579 | RO2959Hydrochloride | 1219927-22-6 | 1g | $2600 | 2021-12-16 | Buy |
RO2959 Hydrochloride Chemical Properties,Uses,Production
Uses
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2].
Biological Activity
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with IC50 of 402 nM. It is a potent blocker of Orai1/Stim1 channel-mediated calcium storage entry (SOCE) with IC50 of 25 nM. It is also a potent inhibitor of human IL-2 production, effectively blocking T cell receptor-triggered gene expression and T cell functional pathways.
in vitro
RO2959 hydrochloride inhibits Orai1 and Orai3 with IC 50 values of 25 nM and 530 nM, respectively. It blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC < sub> 50 value of 265 nM.
It is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4 + T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction ).
target
| CRAC channel 402 nM (IC 50 ) | Orai1/Stim1 channels 25 nM (IC 50 ) | IL-2
|
IC 50
CRAC channel: 402 nM (IC50); Orai1/Stim1 channels: 25 nM (IC50); IL-2
References
[1] Gang Chen, et al. Characterization of a Novel CRAC Inhibitor That Potently Blocks Human T Cell Activation and Effector Functions. Mol Immunol. 2013 Jul;54(3-4):355-67. DOI:10.1016/j.molimm.2012.12.011
[2] Changbo Zheng, et al. Gastrodin Inhibits Store-Operated Ca 2+ Entry and Alleviates Cardiac Hypertrophy. Front Pharmacol. 2017 Apr 25;8:222. DOI:10.3389/fphar.2017.00222
RO2959 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
RO2959 Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32367 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38795 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4645 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 8427 | 55 |
View Lastest Price from RO2959 Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-28 | RO2959 Hydrochloride
1219927-22-6
|
US $79.00-256.00 / mg | 97.42% | 10g | TargetMol Chemicals Inc. |
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- RO2959 Hydrochloride
1219927-22-6
- US $79.00-256.00 / mg
- 97.42%
- TargetMol Chemicals Inc.