DIPHENYLCYCLOPROPENONE
- CAS No.
- 886-38-4
- Chemical Name:
- DIPHENYLCYCLOPROPENONE
- Synonyms
- Diphencyprone;2,3-DIPHENYLCYCLOPROP-2-EN-1-ONE;2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE;1,2-DIPHENYLCYCLOPROPEN-3-ONE;177377-5G;opropenone;RARECHEM AQ C3 0050;Diphencyclopropenone;α,β-Carbonylstilbene;iphenylcyclopropenone
- CBNumber:
- CB2289953
- Molecular Formula:
- C15H10O
- Molecular Weight:
- 206.24
- MDL Number:
- MFCD00001311
- MOL File:
- 886-38-4.mol
- MSDS File:
- SDS
| Melting point | 118-122 °C (lit.) |
|---|---|
| Boiling point | 305.09°C (rough estimate) |
| Density | 1.232 |
| refractive index | 1.6324 (estimate) |
| storage temp. | Store below +30°C. |
| solubility |
DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM) Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM) |
| form | Crystalline Powder |
| color | Slightly pinkish-orange to beige |
| Merck | 14,3308 |
| BRN | 608049 |
| InChI | InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H |
| InChIKey | HCIBTBXNLVOFER-UHFFFAOYSA-N |
| SMILES | C1(=O)C(C2=CC=CC=C2)=C1C1=CC=CC=C1 |
| LogP | 1.769 (est) |
| CAS DataBase Reference | 886-38-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I7G14NW5EC |
| NCI Drug Dictionary | diphencyprone |
| UNSPSC Code | 12352115 |
| NACRES | NA.22 |
DIPHENYLCYCLOPROPENONE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.20533 | 2,3-Diphenyl-2-cyclopropen-1-one for synthesis | 886-38-4 | 1g | $67.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20533 | 2,3-Diphenyl-2-cyclopropen-1-one for synthesis | 886-38-4 | 5G | $249 | 2024-03-01 | Buy |
| Sigma-Aldrich | 177377 | Diphenylcyclopropenone 98% | 886-38-4 | 1g | $76.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 177377 | Diphenylcyclopropenone 98% | 886-38-4 | 5g | $226 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20533 | 2,3-Diphenyl-2-cyclopropen-1-one for synthesis | 886-38-4 | 500mg | $39.4 | 2023-01-07 | Buy |
DIPHENYLCYCLOPROPENONE Chemical Properties,Uses,Production
Description
Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.
Description
Diphencyprone is a potent contact allergen responsible for occupational contact dermatitis in chemists and dermatological staff.
Chemical Properties
slightly pinkish-orange to beige crystalline
Uses
Diphenylcyclopropenone was used in topical immunotherapy.
Definition
ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.
General Description
Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated.
Contact allergens
Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff
Purification Methods
Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.]
DIPHENYLCYCLOPROPENONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32356 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from DIPHENYLCYCLOPROPENONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-15 | Diphenylcyclopropenone
886-38-4
|
US $29.00 / mg | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-07-03 | Diphenylcyclopropenone
886-38-4
|
US $0.00 / Gram | 10Gram | 99 | 500 | Xi an Biohorlden Industry Trade Co Ltd | |
 |
2025-06-24 | DIPHENYLCYCLOPROPENONE
886-38-4
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Diphenylcyclopropenone
886-38-4
- US $29.00 / mg
- 99.90%
- TargetMol Chemicals Inc.
-
- Diphenylcyclopropenone
886-38-4
- US $0.00 / Gram
- 99
- Xi an Biohorlden Industry Trade Co Ltd
-
- DIPHENYLCYCLOPROPENONE
886-38-4
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd