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ChemicalBook >> CAS DataBase List >>Flumatinib

Flumatinib

CAS No.
895519-90-1
Chemical Name:
Flumatinib
Synonyms
HHGV678;FluMatinib;FLUMATINIB (HHGV678);Flumatinib, 10 mM in DMSO;HHGV-678,Inhibitor,Flumatinib,Bcr-Abl,inhibit,Platelet-derived growth factor receptor,PDGFR,CD117,SCFR,HHGV 678,c-Kit;4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;4-[(4-Methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-
CBNumber:
CB22666871
Molecular Formula:
C29H29F3N8O
Molecular Weight:
562.59
MDL Number:
MFCD18633213
MOL File:
895519-90-1.mol
Last updated:2025-07-15 21:51:00

Flumatinib Properties

Density 1.340±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:100.0(Max Conc. mg/mL);177.75(Max Conc. mM)
form A solid
pka 11.84±0.70(Predicted)
color Off-white to yellow
FDA UNII R4009Y24AI

Flumatinib price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5550 Flumatinib 99.94% 895519-90-1 5mg $84 2021-12-16 Buy
ChemScene CS-5550 Flumatinib 99.94% 895519-90-1 10mg $108 2021-12-16 Buy
ChemScene CS-5550 Flumatinib 99.94% 895519-90-1 50mg $228 2021-12-16 Buy
American Custom Chemicals Corporation API0026221 FLUMATINIB 95.00% 895519-90-1 5MG $504.6 2021-12-16 Buy
DC Chemicals DC11413 Flumatinib >98% 895519-90-1 1g $950 2021-12-16 Buy
Product number Packaging Price Buy
CS-5550 5mg $84 Buy
CS-5550 10mg $108 Buy
CS-5550 50mg $228 Buy
API0026221 5MG $504.6 Buy
DC11413 1g $950 Buy

Flumatinib Chemical Properties,Uses,Production

Uses

Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[3] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320
[4] Gong A, et al. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metab Dispos. 2010 Aug;38(8):1328-40. DOI:10.1124/dmd.110.032326

Flumatinib Preparation Products And Raw materials

Raw materials

Preparation Products

Flumatinib Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 6035 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3479 58

View Lastest Price from Flumatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Flumatinib pictures 2025-07-15 Flumatinib
895519-90-1
 US $30.00-79.00 / mg 99.95% 10g TargetMol Chemicals Inc.
  • Flumatinib pictures
  • Flumatinib
    895519-90-1
  • US $30.00-79.00 / mg
  • 99.95%
  • TargetMol Chemicals Inc.
BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)- 4-[(4-Methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide HHGV678 FLUMATINIB (HHGV678) FluMatinib N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide Flumatinib, 10 mM in DMSO HHGV-678,Inhibitor,Flumatinib,Bcr-Abl,inhibit,Platelet-derived growth factor receptor,PDGFR,CD117,SCFR,HHGV 678,c-Kit 4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide 895519-90-1 C29H29F3N8O API