4-Chloroquinoline-6-carboxylic acid ethyl ester
- CAS No.
- 148018-34-2
- Chemical Name:
- 4-Chloroquinoline-6-carboxylic acid ethyl ester
- Synonyms
- CAS:148018-34-2;Ethyl 4-chloro-6-quinolinecarboxylate;ethyl 4-chloroquinoline-6-carboxylate;4-Chloroquinoline-6-carboxylic acid ethyl ester;6-Quinolinecarboxylic acid, 4-chloro-, ethyl ester
- CBNumber:
- CB22511504
- Molecular Formula:
- C12H10ClNO2
- Molecular Weight:
- 235.67
- MDL Number:
- MFCD16250588
- MOL File:
- 148018-34-2.mol
4-Chloroquinoline-6-carboxylic acid ethyl ester price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0368892 | ETHYL-4-CHLOROQUINOLINE-6-CARBOXYLATE 95.00% | 148018-34-2 | 5MG | $499.44 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0368892 | ETHYL-4-CHLOROQUINOLINE-6-CARBOXYLATE 95.00% | 148018-34-2 | 1G | $982.8 | 2021-12-16 | Buy |
| Labseeker | SC-44820 | 4-Chloroquinoline-6-carboxylicacidethylester 95 | 148018-34-2 | 2g | $1166 | 2021-12-16 | Buy |
| Chemenu | CM144480 | ethyl4-chloroquinoline-6-carboxylate 97% | 148018-34-2 | 5g | $1636 | 2021-12-16 | Buy |
| Alichem | 148018342 | Ethyl4-chloroquinoline-6-carboxylate | 148018-34-2 | 5g | $1663.45 | 2021-12-16 | Buy |
4-Chloroquinoline-6-carboxylic acid ethyl ester Chemical Properties,Uses,Production
Synthesis
127286-04-8
148018-34-2
The general procedure for the synthesis of ethyl 4-chloroquinoline-6-carboxylate from the compound (CAS:127286-04-8) was as follows: intermediate 41 (3 g, 13.8 mmol) was mixed with phosphorus trichloride (8 mL) and the reaction was stirred at 120 °C for 3 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and subsequently quenched by adding crushed ice to the residue. Next, saturated aqueous sodium bicarbonate solution with ethyl acetate was added to the mixture to form a two-phase system. The organic and aqueous phases were separated and the aqueous phase was then extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered to remove the desiccant, and the filtrate was evaporated under vacuum to remove the volatile components. Finally, the target product ethyl 4-chloroquinoline-6-carboxylate (2.19 g, 67% yield) was purified by silica gel column chromatography.
References
[1] Patent: US2008/234267, 2008, A1. Location in patent: Page/Page column 25
4-Chloroquinoline-6-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49983 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2208 | 55 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 882 | 52 | |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579 | sales@zeroschem.com | China | 1359 | 59 |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1183 | 57 |
