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ChemicalBook >> CAS DataBase List >>1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-

CAS No.
2416844-79-4
Chemical Name:
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-
Synonyms
IHMT-TRK-284;1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-
CBNumber:
CB212771642
Molecular Formula:
C25H27N7OS
Molecular Weight:
473.59
MDL Number:
MOL File:
2416844-79-4.mol
Last updated:2025-07-17 08:36:09

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Properties

Density 1.339±0.06 g/cm3(Predicted)
pka 9.06±0.50(Predicted)

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Chemical Properties,Uses,Production

Uses

IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].

IC 50

TrkB: 0.7 nM (IC50); TrkC: 2.6 nM (IC50); TrkA: 10.5 nM (IC50); CSF1R: 1.2 nM (IC50); PDGFRα: 24.2 nM (IC50); PDGFRβ: 95.7 nM (IC50); Abl1: 83.6 nM (IC50); KIT: 2167 nM (IC50)

References

[1] Beilei Wang, et al. Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistan DOI:10.1016/j.ejmech.2020.112744

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19927 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9343 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 24803 58

View Lastest Price from 1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IHMT-TRK-284 pictures 2025-07-17 IHMT-TRK-284
2416844-79-4
 US $3520.00-2785.00 / mg 10g TargetMol Chemicals Inc.
  • IHMT-TRK-284 pictures
  • IHMT-TRK-284
    2416844-79-4
  • US $3520.00-2785.00 / mg
  • TargetMol Chemicals Inc.
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- IHMT-TRK-284 2416844-79-4