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ChemicalBook >> CAS DataBase List >>(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide

CAS No.
1314796-00-3
Chemical Name:
(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide
Synonyms
hGPR91 antagonist 1;hGPR91 antagonist 1, 10 mM in DMSO;Inhibitor,inhibit,hGPR91 antagonist 1,hGPR-91 antagonist 1;(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)ethyl)acetamide;Benzeneacetamide, N-[(1S)-1-[4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]ethyl]-4-(1,8-naphthyridin-2-yl)-;(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide
CBNumber:
CB15431549
Molecular Formula:
C31H23F4N3O
Molecular Weight:
529.53
MDL Number:
MFCD31811561
MOL File:
1314796-00-3.mol
Last updated:2025-07-21 13:20:27

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide Properties

Melting point 198-200 °C
Boiling point 708.6±60.0 °C(Predicted)
Density 1.286±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 14.74±0.46(Predicted)
form Solid
color White to off-white

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide Chemical Properties,Uses,Production

Description

HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM[1]. IC50: 7 μM (HGPR91)[1]

HGPR91 antagonist 1 leads to 59, 76% inhibition of δMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM[1]. Animal Model: Wistar rats[1]

Uses

hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC50 of 7 nM for human GPR91[1].

in vivo

HGPR91 antagonist 1 (Compound 4c) leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM[1].

Animal Model:Wistar rats[1]
Dosage:100 mg/kg
Administration:I.p.; 2 and 4 hours
Result:Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours.

References

[1]. Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602.

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide Suppliers

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TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32368 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38801 58
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Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3210 58
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TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24981 58

View Lastest Price from (S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
hGPR91 antagonist 1 pictures 2025-07-21 hGPR91 antagonist 1
1314796-00-3
 US $87.00-313.00 / mg 98.89% 10g TargetMol Chemicals Inc.
hGPR91 antagonist 1 pictures 2025-07-03 hGPR91 antagonist 1
1314796-00-3
 US $87.00-313.00 / mg 98.89% 10g TargetMol Chemicals Inc.

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide Spectrum

(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide hGPR91 antagonist 1 Inhibitor,inhibit,hGPR91 antagonist 1,hGPR-91 antagonist 1 Benzeneacetamide, N-[(1S)-1-[4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]ethyl]-4-(1,8-naphthyridin-2-yl)- (S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)ethyl)acetamide hGPR91 antagonist 1, 10 mM in DMSO 1314796-00-3