PD184352
- CAS No.
- 212631-79-3
- Chemical Name:
- PD184352
- Synonyms
- CS-333;Ci-1040;PD184352;PD 184352, >=98%;CI-1040, PD-184352;PD184352 USP/EP/BP;CI-1040, 10 mM in DMSO;PD 184352;CI-1040;PD-184352;CI1040;PD-184352; CI 1040 (PD184352);2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME
- CBNumber:
- CB1500875
- Molecular Formula:
- C17H14ClF2IN2O2
- Molecular Weight:
- 478.66
- MDL Number:
- MFCD02683961
- MOL File:
- 212631-79-3.mol
- MSDS File:
- SDS
| Melting point | 166-169°C |
|---|---|
| Density | 1.747±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥30mg/mL |
| pka | -5.58±0.50(Predicted) |
| form | powder |
| color | white to tan |
| FDA UNII | R3K9Y00J04 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
PD184352 price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0181 | PD 184352 ≥98% (HPLC) | 212631-79-3 | 5mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0181 | PD 184352 ≥98% (HPLC) | 212631-79-3 | 25mg | $516 | 2024-03-01 | Buy |
| TCI Chemical | P2174 | PD 184352 | 212631-79-3 | 25MG | $243 | 2024-03-01 | Buy |
| TCI Chemical | P2174 | PD 184352 | 212631-79-3 | 100MG | $726 | 2024-03-01 | Buy |
| Cayman Chemical | 11580 | CI-1040 ≥98% | 212631-79-3 | 5mg | $81 | 2024-03-01 | Buy |
PD184352 Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Beige Solid
Uses
An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Potent MEK inhibitor.
Definition
ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.
Biological Activity
pd184352 (also known as ci-1040), a benzhydroxamate derivative, is a potent and highly selective mek1/2, two members of the family of mapkks, inhibitor that inhibits purified mek1 with ic50 of 17 nm in a non-atp and non-erk1/2 competitive manner [1].pd184352 binds to a hydrophobic pocket, which is located in a region with low sequence homology to other kinases, adjacent to the mg-atp binding site of mek1 and mek2 inducing a conformational change in un-phosphorylated mek1/2 and hence inactivating the un-phosphorylated mek1/2 [1].pd184352 has been found to be actively against tumors, where it inhibits the growth of colon carcinomas in mouse xenograft models [1].
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.
storage
Store at +4°C
References
[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8.
PD184352 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5745 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32354 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22827 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
